Protein Alignment Ack-like and EPHA6

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: XP_006713655.1
• Gene: EPHA6 / 285220
• HGNCID: 19296
• Length: 1146
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 155/520 - (29%)
• Similarity: 214/520 - (41%)
• Gaps: 147/520 - (28%)

  Fly    11 FLTESELQQYYNA-VKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIK 74
            ||.....|.|..| :|:|.|..|..|     :..|||.|:.                 :|:.
Human   679 FLITGRCQWYIKAKMKSEEKRRNHLQ-----NGHLRFPGIK-----------------TYID--- 718

  Fly    75 RLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQL 139
                 |.|.    |.|                 |||....|         |.|.|: .|.:.:.:
Human   719 -----PDTY----EDP-----------------SLAVHEFA---------KEIDPS-RIRIERVI 747

  Fly   140 GTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVL-- 201
            |.||||.|..| :.:.|...|.||||.|....|.....:||:||:||...:|.||:||.|||.
Human   748 GAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMDRQRRDFLREASIMGQFDHPNIIRLEGVVTKR 812

  Fly   202 ----------------------------------------ATDSLMLVTELAHLRSLLECLKDSG 226
                                                    |...:|:|.|.....||     ||.
Human   813 SFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENGSL-----DSF 872

  Fly   227 LRV--SFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGK 289
            ||.  ...|:..|......|.:||:||.....:|||||||||||.|....|:|||||||.|....
Human   873 LRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDP 937

  Fly   290 D-YYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAI 353
            : .|.|...   |:||.|.|||.|.|.:|::|||.|::|:.:||:.|||.:|:..::...::.:|
Human   938 EAAYTTTGG---KIPIRWTAPEAIAYRKFSSASDAWSYGIVMWEVMSYGERPYWEMSNQDVILSI 999

  Fly   354 DAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDM--KPEQLKAVVNCTEPKKD 416
            : ..| ||..|..||:..:.||:.|||.:...||:|.:|...|..:  .|..|..:|.
Human  1000 E-EGY-RLPAPMGCPASLHQLMLHCWQKERNHRPKFTDIVSFLDKLIRNPSALHTLVE------- 1055

  Fly   417 HLLYRQGDIISVLDRNTGT----PFWKGV---LSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVS 474
                   ||: |:..:.|.    |.:..|   |.:.|.|.:. :|.||  .|.  :|.|..||:|
Human  1056 -------DIL-VMPESPGEVPEYPLFVTVGDWLDSIKMGQYK-NNFVA--AGF--TTFDLISRMS 1107

  Fly   475  474
            Human  1108  1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	14/54 (26%)
		STYKc	133..396	CDD:214568	107/308 (35%)
		PTKc_Ack_like	137..398	CDD:270636	107/306 (35%)
		SH3	400..454	CDD:214620	12/60 (20%)
		CRIB	486..525	CDD:238077
EPHA6	XP_006713655.1	EphR_LBD_A6	128..300	CDD:198452
		fn3	427..521	CDD:278470
		FN3	537..644	CDD:238020
		EphA2_TM	664..736	CDD:291255	24/116 (21%)
		PTKc_EphR_A	736..1044	CDD:270651	110/318 (35%)
		Pkinase_Tyr	741..1040	CDD:285015	107/308 (35%)
		SAM	1068..1135	CDD:197735	14/45 (31%)
		SAM_EPH-A6	1071..1134	CDD:188946	14/42 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910