DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Hck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_037317.2	Gene:	Hck / 25734	RGDID:	2785	Length:	524	Species:	Rattus norvegicus

Alignment Length:	445	Identity:	136/445 - (30%)
Similarity:	210/445 - (47%)	Gaps:	96/445 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 AQFKYAA--DEDLRF------IGLSRP----EIRRLRKFYEKHFPHSYLSKI------------- 73
            |.:.|.|  .|||.|      :.|...    :.|.|....|.:.|.:|::::
  Rat    83 ALYDYEAIHREDLSFQKGDQMVVLEESGEWWKARSLATKKEGYIPSNYVARVNSLETEEWFFKGI 147

  Fly    74 -----KRLLQAPGTMV------------------KREEAPGGGSQV------ALDG-----SSAS 104
                 :|.|.|||.|:                  .|:..|..|..|      .||.     |..|
  Rat   148 SRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRS 212

  Fly   105 ACSSL--------AAKNGASSPSKVP-----------NNKHIIPADSISVNKQLGTGEFGIVQQG 150
            ..|||        ..|:|......||           .:...||.:|:.:.|:||.|:||.|...
  Rat   213 TFSSLQELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMA 277

  Fly   151 VWSNGNERIQVAIKCLCRERMQSNPME-FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAH 214
            .:   |:..:||:|.:   :..|..:| ||.||.:|.:::|:.:|:|:.|| :.:.:.:|||...
  Rat   278 TY---NKHTKVAVKTM---KPGSMSVEAFLAEANLMKTLQHDKLVKLHAVV-SQEPIFIVTEFMA 335

  Fly   215 LRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISD 278
            ..|||:.|| :.|   |...:|.|.:|:.||..||.::||:..|||||.|.||||.:....||:|
  Rat   336 KGSLLDFLKSEEG---SKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIAD 397

  Fly   279 FGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAA 343
            |||:|.: ...:|   ......|.||.|.|||.||:..||..||||:||:.|.|:.:||..|:..
  Rat   398 FGLARII-EDNEY---TAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPG 458

  Fly   344 LTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            ::..:::.|::  :..|:.:||.||.|.|::|::||::...:||.|..|...|.|
  Rat   459 MSNPEVIRALE--HGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDD 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	11/42 (26%)
		STYKc	133..396	CDD:214568	97/264 (37%)
		PTKc_Ack_like	137..398	CDD:270636	98/262 (37%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Hck	NP_037317.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..71
		SH3	80..135	CDD:302595	13/51 (25%)
		SH2_Src_HCK	138..241	CDD:198226	21/102 (21%)
		PKc_like	252..522	CDD:304357	102/276 (37%)
		Pkinase_Tyr	260..509	CDD:285015	97/264 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920