DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Ptk2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_038934399.1	Gene:	Ptk2 / 25614	RGDID:	3443	Length:	1140	Species:	Rattus norvegicus

Alignment Length:	444	Identity:	147/444 - (33%)
Similarity:	220/444 - (49%)	Gaps:	80/444 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVW-SNGNERIQVAIKCLCRERMQSNPME-FLKEAAIMHSIEH 190
            |..:.|.:.:.:|.|:||.|.|||: |..|..:.|||| .|:.....:..| ||:||..|...:|
  Rat   502 IQRERIELGRCIGEGQFGDVHQGVYLSPENPALAVAIK-TCKNCTSDSVREKFLQEALTMRQFDH 565

  Fly   191 ENIVRLYGVVLATDS----LMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYL 251
            .:||:|.||:  |::    :|.:..|..|||.|:..|.|      |.:.:|..:|.|:...:.||
  Rat   566 PHIVKLIGVI--TENPVWIIMELCTLGELRSFLQVRKYS------LDLASLILYAYQLSTALAYL 622

  Fly   252 EQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLR 316
            |.||.:|||:||||:||.|.|.||:.||||||.: ....|||.:..   ||||.|.|||.||:.|
  Rat   623 ESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYM-EDSTYYKASKG---KLPIKWMAPESINFRR 683

  Fly   317 FTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQD 381
            ||:|||||.||||:||:..:|.:|:..:....::..|:  |.:||..|..||...|:||.|||..
  Rat   684 FTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE--NGERLPMPPNCPPTLYSLMTKCWAY 746

  Fly   382 DAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFW------KG 440
            |.::||||.|:..||..:..|:               ..:|.:.:.:..|...|..|      :.
  Rat   747 DPSRRPRFTELKAQLSTILEEE---------------KVQQEERMRMESRRQATVSWDSGGSDEA 796

  Fly   441 VLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDG 505
            .....:.||.:|.::..|   .||         ..|.:.            .|.::.:|:.|..|
  Rat   797 PPKPSRPGYPSPRSSEGF---YPS---------PQHMVQ------------TNHYQISGYPGSHG 837

  Fly   506 --ATFGDI-----AFLGSSQNYNHVPKQIVTPYKPS-EDIEQTPL-----LLPP 546
              |..|.|     :.|..::.:||.|:: ::.::|| ||.....|     :|||
  Rat   838 IPAMAGSIYPGQASLLDQTELWNHRPQE-MSMWQPSVEDSAALDLRGMGQVLPP 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	113/268 (42%)
		PTKc_Ack_like	137..398	CDD:270636	114/266 (43%)
		SH3	400..454	CDD:214620	8/59 (14%)
		CRIB	486..525	CDD:238077	10/45 (22%)
Ptk2	XP_038934399.1	FERM_N_2	79..174	CDD:407875
		B41	80..302	CDD:214604
		FERM_C_FAK1	298..408	CDD:270011
		PTKc_FAK	500..769	CDD:133187	117/296 (40%)
		Focal_AT	1004..1133	CDD:397606
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910