DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and FYN

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001357458.1	Gene:	FYN / 2534	HGNCID:	4037	Length:	537	Species:	Homo sapiens

Alignment Length:	297	Identity:	113/297 - (38%)
Similarity:	162/297 - (54%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            ||.:|:.:.|:||.|:||.|..|.| |||.:  ||||.|....|  :|..||:||.||..::|:.
Human   266 IPRESLQLIKRLGNGQFGEVWMGTW-NGNTK--VAIKTLKPGTM--SPESFLEEAQIMKKLKHDK 325

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|:||.|| :.:.:.:|||..:..|||:.|||...|.  |.:|.|.:.|.|:..||.|:|:...|
Human   326 LVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRA--LKLPNLVDMAAQVAAGMAYIERMNYI 387

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.:.||||.:....||:||||:|.: ...:|   ......|.||.|.|||...|.|||..||
Human   388 HRDLRSANILVGNGLICKIADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTIKSD 448

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:.|.|:.:.|..|:..:...::||.::. .| |:..|..||...:.||:.||:.|..:||
Human   449 VWSFGILLTELVTKGRVPYPGMNNREVLEQVER-GY-RMPCPQDCPISLHELMIHCWKKDPEERP 511

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..:...|.|        ....|||:     |:.|:
Human   512 TFEYLQSFLED--------YFTATEPQ-----YQPGE 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	104/260 (40%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077
FYN	NP_001357458.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..35
		SH3_Fyn_Yrk	85..140	CDD:212939
		SH2_Src_Fyn_isoform_a_like	145..245	CDD:198281
		PTKc_Fyn	261..534	CDD:270655	112/294 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010