DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Syk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_036890.2	Gene:	Syk / 25155	RGDID:	3796	Length:	629	Species:	Rattus norvegicus

Alignment Length:	278	Identity:	103/278 - (37%)
Similarity:	159/278 - (57%)	Gaps:	18/278 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM---EFL 179
            |.:|..::.::..:    :.:||:|.||.|::|.:........||:|.|..|  .::|.   |.|
  Rat   354 PKEVYLDRKLLTLE----DNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--ANDPALKDELL 412

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQI 244
            .||.:|..:::..|||:.|:..| :|.|||.|:|.|..|.:.|:.:    ..:....:.|...|:
  Rat   413 AEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN----RHIKDKNIIELVHQV 472

  Fly   245 CNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAP 309
            ..||:|||:...:||||||||:|:.::...||||||||:||...::|||.  ..:.|.|:.|.||
  Rat   473 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA--QTHGKWPVKWYAP 535

  Fly   310 ECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTL 374
            |||||.:|::.||||:|||.:||.||||.:|:..:.|.::...::  ..:|:..|..||.|.|.|
  Rat   536 ECINYFKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE--KGERMGCPPGCPREMYDL 598

  Fly   375 MMKCWQDDAAKRPRFGEI 392
            |..||..|...||.|..:
  Rat   599 MNLCWTYDVENRPGFAAV 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	101/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/259 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Syk	NP_036890.2	SH2_N-SH2_Zap70_Syk_like	12..115	CDD:198191
		Interdomain A. /evidence=ECO:0000250	107..166
		SH2_C-SH2_Syk_like	163..261	CDD:198264
		Interdomain B. /evidence=ECO:0000250	259..364		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..330
		PTKc_Syk	370..625	CDD:133247	101/258 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000