DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Fyn

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_006256584.1	Gene:	Fyn / 25150	RGDID:	2641	Length:	575	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	113/297 - (38%)
Similarity:	162/297 - (54%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            ||.:|:.:.|:||.|:||.|..|.| |||.:  ||||.|....|  :|..||:||.||..::|:.
  Rat   304 IPRESLQLIKRLGNGQFGEVWMGTW-NGNTK--VAIKTLKPGTM--SPESFLEEAQIMKKLKHDK 363

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|:||.|| :.:.:.:|||..:..|||:.|||...|.  |.:|.|.:.|.|:..||.|:|:...|
  Rat   364 LVQLYAVV-SEEPIYIVTEYMNKGSLLDFLKDGEGRA--LKLPNLVDMAAQVAAGMAYIERMNYI 425

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.:.||||.:....||:||||:|.: ...:|   ......|.||.|.|||...|.|||..||
  Rat   426 HRDLRSANILVGNGLICKIADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTIKSD 486

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:.|.|:.:.|..|:..:...::||.::. .| |:..|..||...:.||:.||:.|..:||
  Rat   487 VWSFGILLTELVTKGRVPYPGMNNREVLEQVER-GY-RMPCPQDCPISLHELMIHCWKKDPEERP 549

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..:...|.|        ....|||:     |:.|:
  Rat   550 TFEYLQGFLED--------YFTATEPQ-----YQPGE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	104/260 (40%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281
		PTKc_Fyn	299..572	CDD:270655	112/294 (38%)
		Pkinase_Tyr	309..558	CDD:285015	103/262 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010