DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Yes1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_006245737.1	Gene:	Yes1 / 24884	RGDID:	3977	Length:	541	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	111/297 - (37%)
Similarity:	154/297 - (51%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            ||.:|:.:..:||.|.||.|..|.| ||..:  ||||.|....|.  |..||:||.||..:.|:.
  Rat   270 IPRESLRLEVKLGQGCFGEVWMGTW-NGTTK--VAIKTLKPGTMM--PEAFLQEAQIMKKLRHDK 329

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|.||.|| :.:.:.:|||.....|||:.||:...:  :|.:|.|.:.|.||.:||.|:|:...|
  Rat   330 LVPLYAVV-SEEPIYIVTEFMSKGSLLDFLKEGDGK--YLKLPQLVDMAAQIADGMAYIERMNYI 391

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.|.||||......||:||||:|.: ...:|   ......|.||.|.|||...|.|||..||
  Rat   392 HRDLRAANILVGENLVCKIADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGRFTIKSD 452

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:...|:.:.|..|:..:...::||.::. .| |:..|..||...:.||..||:.|..:||
  Rat   453 VWSFGILQTELVTKGRVPYPGMVNREVLEQVER-GY-RMPCPQGCPESLHELMNLCWKKDPDERP 515

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..|...|.|        ....|||:     |:.|:
  Rat   516 TFEYIQSFLED--------YFTATEPQ-----YQPGE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	101/262 (39%)
		PTKc_Ack_like	137..398	CDD:270636	102/260 (39%)
		SH3	400..454	CDD:214620	5/25 (20%)
		CRIB	486..525	CDD:238077
Yes1	XP_006245737.1	SH3_Yes	92..149	CDD:212940
		SH2_Src_family	152..251	CDD:199827
		PTKc_Yes	262..540	CDD:270654	111/297 (37%)
		Pkinase_Tyr	275..524	CDD:285015	101/262 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010