DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Ephb1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001097998.1	Gene:	Ephb1 / 24338	RGDID:	2556	Length:	984	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	118/301 - (39%)
Similarity:	164/301 - (54%)	Gaps:	16/301 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            |....:.:.:.:|.||||.|.:| :...|...|.||||.|.....:....:||.||:||...:|.
  Rat   614 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP 678

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVS--FLTIPTLCEFALQICNGMRYLEQK 254
            ||:||.|||..:..:|::||.....:|     ||.||.:  ..|:..|......|..||:||.:.
  Rat   679 NIIRLEGVVTKSRPVMIITEFMENGAL-----DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEM 738

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNL--KLPIAWCAPECINYLRF 317
            ..:|||||||||||.|....|:|||||||.|  ..|.....:..:|  |:|:.|.|||.|.|.:|
  Rat   739 NYVHRDLAARNILVNSNLVCKVSDFGLSRYL--QDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKF 801

  Fly   318 TNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDD 382
            |:|||||::|:.:||:.|:|.:|:..::...::.||: .:| ||..|..||:..:.||:.|||.|
  Rat   802 TSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIE-QDY-RLPPPMDCPAALHQLMLDCWQKD 864

  Fly   383 AAKRPRFGEIYDQLPDM--KPEQLKAVVNCTEPKKDHLLYR 421
            ...||||.||.:.|..|  .|..||.|...|......||.|
  Rat   865 RNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDR 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	107/267 (40%)
		PTKc_Ack_like	137..398	CDD:270636	108/265 (41%)
		SH3	400..454	CDD:214620	8/22 (36%)
		CRIB	486..525	CDD:238077
Ephb1	NP_001097998.1	EphR_LBD_B1	20..195	CDD:198444
		fn3	326..412	CDD:394996
		fn3	435..518	CDD:394996
		EphA2_TM	542..616	CDD:405290	1/1 (100%)
		PTKc_EphR_B	614..882	CDD:173638	109/276 (39%)
		SAM_EPH-B1	908..975	CDD:188950
		PDZ-binding. /evidence=ECO:0000255	982..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910