DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Zap70

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001276695.1	Gene:	Zap70 / 22637	MGIID:	99613	Length:	642	Species:	Mus musculus

Alignment Length:	278	Identity:	111/278 - (39%)
Similarity:	165/278 - (59%)	Gaps:	15/278 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SSPSKVPNNKHIIPADSISV-NKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFL 179
            |.|.::.:.|..:..:::.| :.:||.|.||.|:|||:....::|.||||.|.:...:::..|.:
Mouse   343 SDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADKDEMM 407

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELA---HLRSLLECLKDSGLRVSFLTIPTLCEFA 241
            :||.|||.:::..||||.||..| ::||||.|:|   .|...|...|:.      :.:..:.|..
Mouse   408 REAQIMHQLDNPYIVRLIGVCQA-EALMLVMEMAGGGPLHKFLLGKKEE------IPVSNVAELL 465

  Fly   242 LQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAW 306
            .|:..||:|||:|..:||||||||:|:.::...||||||||:|||....||......  |.|:.|
Mouse   466 HQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAG--KWPLKW 528

  Fly   307 CAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEY 371
            .||||||:.:|::.||||::||.:||.||||.:|:..:.|.::|:.|  ...:|:|.|..||.|.
Mouse   529 YAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLDFI--KQGKRMECPPECPPEM 591

  Fly   372 YTLMMKCWQDDAAKRPRF 389
            |.||..||......||.|
Mouse   592 YALMSDCWIYKWEDRPDF 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	108/261 (41%)
		PTKc_Ack_like	137..398	CDD:270636	107/256 (42%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Zap70	NP_001276695.1	SH2_N-SH2_Zap70_Syk_like	32..135	CDD:198191
		SH2	176..280	CDD:301589
		PTKc_Zap-70	356..624	CDD:270686	108/265 (41%)
		Pkinase_Tyr	366..616	CDD:285015	107/255 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910