DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and FES

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001996.1	Gene:	FES / 2242	HGNCID:	3657	Length:	822	Species:	Homo sapiens

Alignment Length:	341	Identity:	122/341 - (35%)
Similarity:	170/341 - (49%)	Gaps:	27/341 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHI 127
            :||....|..:.||           |..|..|...|.....|....|..|:|......||.:|.:
Human   502 RHFIIQSLDNLYRL-----------EGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPKDKWV 555

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSN-PMEFLKEAAIMHSIEHE 191
            :..:.:.:.:|:|.|.||.|..|.....|  ..||:|. |||.:..: ..:||:||.|:....|.
Human   556 LNHEDLVLGEQIGRGNFGEVFSGRLRADN--TLVAVKS-CRETLPPDLKAKFLQEARILKQYSHP 617

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            |||||.||......:.:|.||......|..|:..|.|   |.:.||.:.......||.|||.|..
Human   618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGAR---LRVKTLLQMVGDAAAGMEYLESKCC 679

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSR--ALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            |||||||||.||..|:.:||||||:||  |.||    |..:..:. ::|:.|.|||.:||.|:::
Human   680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGV----YAASGGLR-QVPVKWTAPEALNYGRYSS 739

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            .||||:||:.|||.||.|..|:..|:..|..|.::...  ||..|:.||...:.||.:||..:..
Human   740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGG--RLPCPELCPDAVFRLMEQCWAYEPG 802

  Fly   385 KRPRFGEIYDQLPDMK 400
            :||.|..||.:|..::
Human   803 QRPSFSTIYQELQSIR 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	0/1 (0%)
		STYKc	133..396	CDD:214568	105/265 (40%)
		PTKc_Ack_like	137..398	CDD:270636	106/263 (40%)
		SH3	400..454	CDD:214620	0/1 (0%)
		CRIB	486..525	CDD:238077
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300
		F-BAR_Fes	7..239	CDD:153369
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..421
		SH2_Fps_family	453..537	CDD:198224	10/45 (22%)
		Pkinase_Tyr	561..814	CDD:285015	105/265 (40%)
		PTKc_Fes	564..815	CDD:270667	105/263 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910