DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Syk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001185906.1	Gene:	Syk / 20963	MGIID:	99515	Length:	629	Species:	Mus musculus

Alignment Length:	275	Identity:	103/275 - (37%)
Similarity:	158/275 - (57%)	Gaps:	18/275 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 PSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM---EFL 179
            |.:|..::.::..:    :.:||:|.||.|::|.:........||:|.|..|  .::|.   |.|
Mouse   354 PKEVYLDRSLLTLE----DNELGSGNFGTVKKGYYQMKKVVKTVAVKILKNE--ANDPALKDELL 412

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQI 244
            .||.:|..:::..|||:.|:..| :|.|||.|:|.|..|.:.|:.:    ..:....:.|...|:
Mouse   413 AEANVMQQLDNPYIVRMIGICEA-ESWMLVMEMAELGPLNKYLQQN----RHIKDKNIIELVHQV 472

  Fly   245 CNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAP 309
            ..||:|||:...:||||||||:|:.::...||||||||:||...::|||.  ..:.|.|:.|.||
Mouse   473 SMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA--QTHGKWPVKWYAP 535

  Fly   310 ECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTL 374
            |||||.:|::.||||:|||.:||.||||.:|:..:.|.::...::  ..:|:..|..||.|.|.|
Mouse   536 ECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLE--KGERMGCPAGCPREMYDL 598

  Fly   375 MMKCWQDDAAKRPRF 389
            |..||..|...||.|
Mouse   599 MNLCWTYDVENRPGF 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	101/260 (39%)
		PTKc_Ack_like	137..398	CDD:270636	101/256 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Syk	NP_001185906.1	SH2_N-SH2_Zap70_Syk_like	12..115	CDD:198191
		Interdomain A	107..166
		SH2_C-SH2_Syk_like	163..261	CDD:198264
		Interdomain B	259..364		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..328
		PTKc_Syk	370..625	CDD:133247	101/255 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910