DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Srms

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_035611.3	Gene:	Srms / 20811	MGIID:	101865	Length:	507	Species:	Mus musculus

Alignment Length:	394	Identity:	121/394 - (30%)
Similarity:	194/394 - (49%)	Gaps:	66/394 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGT-MVKREEAPGGGSQVALDGSSA 103
            :|:...|.|:||.:.::|           .||.    ..|||. :::..|:..||..::: .:.|
Mouse   131 SDQPWYFSGISRAQAQQL-----------LLSP----ANAPGAFLIRPSESSIGGYSLSV-RAQA 179

  Fly   104 SAC---------SSLAAKNGASSPS-------------------------KVP--NNKHIIPADS 132
            ..|         .||..:.|...||                         ::|  .::...|...
Mouse   180 KVCHYRICMAPSGSLYLQEGQLFPSLDALLAYYKTNWKLIQNPLLQPCIPQIPLVQDEWERPRSE 244

  Fly   133 ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLY 197
            ..:.::||.|.||.|.:|:|...   |.||:|.:....|:.  .:..||...:.|:.||.::||:
Mouse   245 FVLRRKLGEGFFGEVWEGLWLGS---IPVAVKVIKSADMKL--ADLTKEIEALKSLRHERLIRLH 304

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLA 262
            .:....:.:.:||||....:|...|..|..:.  |::|.|..||.|:..||.|||::|::|||||
Mouse   305 AICSLGEPVYIVTELMGKGNLQVYLGSSEGKA--LSLPHLLGFACQVAEGMSYLEERRVVHRDLA 367

  Fly   263 ARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFG 327
            |||:||......|::||||:|.|  ..|.|..  :...|:|:.|.|||..||..|:..||||:||
Mouse   368 ARNVLVGDDLTCKVADFGLARLL--KDDVYSP--SSGSKIPVKWTAPEAANYRVFSQKSDVWSFG 428

  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392
            :.|:|:|:||..|:..:|..:.|:.| :..| ||.:|..||:|.|.||::||:....:||.|..:
Mouse   429 ILLYEVFTYGQCPYEGMTNHETLQQI-SRGY-RLPRPAVCPAEVYVLMVECWKGSPEERPTFAIL 491

  Fly   393 YDQL 396
            .::|
Mouse   492 REKL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	6/24 (25%)
		STYKc	133..396	CDD:214568	97/262 (37%)
		PTKc_Ack_like	137..398	CDD:270636	98/260 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Srms	NP_035611.3	SH3	70..124	CDD:302595
		SH2_Srm	134..212	CDD:198223	20/93 (22%)
		PTKc_Srm_Brk	238..498	CDD:133248	99/271 (37%)
		STYKc	246..495	CDD:214568	97/261 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920