DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Ptk6

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_033210.1	Gene:	Ptk6 / 20459	MGIID:	99683	Length:	451	Species:	Mus musculus

Alignment Length:	436	Identity:	122/436 - (27%)
Similarity:	195/436 - (44%)	Gaps:	88/436 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 FKYAADEDLRFIGLSRPEIRRLRKFY--------------EKHFPHSYL---------------- 70
            ||...||:|.|.......:.:..:.:              |.:.||:||
Mouse    19 FKARTDEELSFQAGDLLHVTKKEELWWWATLLDAEGKALAEGYVPHNYLAEKETVESEPWFFGCI 83

  Fly    71 --SKIKRLLQAPGT-----MVKREEAPGGGSQVAL----------------------DGSSASAC 106
              |:....|||...     :::..:.||....:::                      :..|.|..
Mouse    84 SRSEAMHRLQAEDNSKGAFLIRVSQKPGADYVLSVRDAQAVRHYRIWKNNEGRLHLNEAVSFSNL 148

  Fly   107 SSLAAKNGASSPS-----KVPNNKHII-----------PADSISVNKQLGTGEFGIVQQGVWSNG 155
            |.|...:...|.|     .:|..||..           |.:..::.|:||.|.||.|.:.:|..
Mouse   149 SELVDYHKTQSLSHGLQLSMPCWKHKTEPLPHWDDWERPREEFTLCKKLGAGYFGEVFEALWKG- 212

  Fly   156 NERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLE 220
              ::.||:|.:.|:.: .:...|..|...|..:.|::|:.||.|..|.|.:.::|||....:||:
Mouse   213 --QVHVAVKVISRDNL-LHQHTFQAEIQAMKKLRHKHILSLYAVATAGDPVYIITELMPKGNLLQ 274

  Fly   221 CLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRAL 285
            .|:||..:.  |.|..|.:||.|:..||.|||.:..|||||||||:||...:..|:.||||:|.
Mouse   275 LLRDSDEKA--LPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLVTENNLCKVGDFGLARL- 336

  Fly   286 GVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQIL 350
             |.:|.|.::.:   .:|..|.|||.::...::..||||:|||.|.|:||.|..|:..::..:..
Mouse   337 -VKEDIYLSHEH---NVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRGQMPYPGMSNHETF 397

  Fly   351 EAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            ..:|| .| |:..|..||...:.||:.||..|..:||.|.::.::|
Mouse   398 LRVDA-GY-RMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKL 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	7/42 (17%)
		STYKc	133..396	CDD:214568	94/262 (36%)
		PTKc_Ack_like	137..398	CDD:270636	95/260 (37%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Ptk6	NP_033210.1	SH3	12..69	CDD:302595	11/49 (22%)
		SH2_PTK6_Brk	75..174	CDD:198221	14/98 (14%)
		Linker	171..190		3/18 (17%)
		PKc_like	184..444	CDD:304357	96/271 (35%)
		STYKc	192..441	CDD:214568	94/261 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010