DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and W01B6.5

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_501826.2	Gene:	W01B6.5 / 189082	WormBaseID:	WBGene00012172	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	92/305 - (30%)
Similarity:	148/305 - (48%)	Gaps:	51/305 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQQGVW--SNGNERIQVAIKCL------CRERMQSNPMEFL 179
            :|...|..|.....|:||.|.||.|:.|..  .:..:.::||:|.|      .||::.    |.|
Worm   258 SNWEFIHEDIALQQKKLGEGAFGEVRIGKMKLKSTKKTVEVAVKMLRNAEVVIREQVG----ELL 318

  Fly   180 KEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCE---FA 241
            .||.:|..::|:|::|.||:.:..:.|.|:||:....:|.|.|:::...|      ||.|   |.
Worm   319 HEARVMRMMDHKNVLRSYGIAVLKEPLYLMTEMCACGALREYLRENQETV------TLAEKLFFV 377

  Fly   242 LQICNGMRYLEQKRLIHRDLAARNILVFSKDKV-KISDFGLSRALGVGKDYYKTNFNVNLKLPIA 305
            :....|::||..::.||||||.||||: |:|:. |||||||::   :.:.|   ......|:|:.
Worm   378 VGSSRGVQYLHSQKTIHRDLAVRNILL-SEDRTPKISDFGLAK---ISERY---EMKEQCKIPVR 435

  Fly   306 WCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSE 370
            :.|||.:....||..:||::||..:||::..|.||... ...|.:..:...| |.|:..:..|||
Worm   436 YLAPETLESFIFTTKTDVFSFGCVIWEIYENGNQPHDG-KNAQTIRNLTKKN-QFLKLTNSAPSE 498

  Fly   371 YYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPE---QLKAVVNCTE 412
            ...|                 |.:::....||   .:..:|.|.|
Worm   499 LRKL-----------------IEERVFTSDPENRCSMTTIVQCAE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	84/274 (31%)
		PTKc_Ack_like	137..398	CDD:270636	84/272 (31%)
		SH3	400..454	CDD:214620	5/16 (31%)
		CRIB	486..525	CDD:238077
W01B6.5	NP_501826.2	SH2	104..241	CDD:301589
		PTKc	272..524	CDD:270623	87/287 (30%)
		TyrKc	272..524	CDD:197581	87/287 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910