DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and T25B9.4

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_501994.1	Gene:	T25B9.4 / 188882	WormBaseID:	WBGene00012010	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	125/493 - (25%)
Similarity:	193/493 - (39%)	Gaps:	104/493 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 KHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNP--MEFLKEAAIMHS 187
            ||    ..|::.|::|.|.:|.|.:|..:.||:....|||.:.::....|.  .|.:.||.:|.|
Worm   128 KH----SQINLIKKVGKGAYGEVFKGTVTRGNKTFNGAIKAMRKDLDAGNEKMKEVMAEARLMRS 188

  Fly   188 IEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLE 252
            :.|.||||..|:.:....:.:|.|..:...|...||.:.   ..||:......|:....|:.::.
Worm   189 LNHPNIVRCRGIAVLEQPVYIVIEFINGGGLDSYLKKNS---QTLTMDQKNRMAISAAWGIEFMH 250

  Fly   253 QKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRF 317
            ...:||||:||||.|..:|:.||:|||||||.   |..|   .....:|:|..|.|||.:....|
Worm   251 SHDIIHRDIAARNCLYDNKNLVKLSDFGLSRK---GSVY---RMKKAMKMPTKWLAPESLTTFTF 309

  Fly   318 TNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDA---PNYQRLEQPDCCPSEYYTLMMK-C 378
            :.||||:.|||.|:|:::.. :|:.|:...:....|.:   ||:.:.     .|.|...::.| .
Worm   310 SGASDVYTFGVLLYEIYTCQ-EPYLAVKAGEAKRYILSGAFPNFTKQ-----APPELNEIVKKSI 368

  Fly   379 WQDDAAKRPRFGEIYDQL---------------PDMKPEQLKAVVNC-----TEPKKDHLLYRQG 423
            :|.|.|||.....|..:|               ||:.||..:...|.     :..||     .:.
Worm   369 YQLDPAKRDTMKVIVKKLETWLDVELVLDENEKPDIDPESNRFNGNMPIRVDSSTKK-----MRN 428

  Fly   424 DIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFLEGLPS---STRDSFSRVSDHRISKRKLRT 485
            |.:.:....|.                    |||....||.   |.|...||.|..:..|:|...
Worm   429 DTVCIPPPETA--------------------TVALPNSLPPITVSARSKNSRKSTLKRKKKKTSK 473

  Fly   486 EMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTS 550
            :..........:......||...       ||:..: |..::|:..|.......||.|....|:|
Worm   474 DSSMTTTTTNTNESEPPADGQVI-------SSETMS-VANKMVSDAKGGSPEMLTPSLEELKPSS 530

  Fly   551 PDSLQTASGYFPEGANSGGAMGTSMNPTFIPSAEHTPK 588
            .:                       |.||:.....|.|
Worm   531 QE-----------------------NETFLNEKNSTAK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	84/268 (31%)
		PTKc_Ack_like	137..398	CDD:270636	84/281 (30%)
		SH3	400..454	CDD:214620	7/58 (12%)
		CRIB	486..525	CDD:238077	5/38 (13%)
T25B9.4	NP_501994.1	SH2_Fps_family	9..109	CDD:198224
		TyrKc	132..386	CDD:197581	84/268 (31%)
		PTKc	136..387	CDD:270623	83/265 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910