DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and R11E3.1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_500644.2	Gene:	R11E3.1 / 187810	WormBaseID:	WBGene00020003	Length:	549	Species:	Caenorhabditis elegans

Alignment Length:	495	Identity:	137/495 - (27%)
Similarity:	212/495 - (42%)	Gaps:	118/495 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TESELQQYYNAVKNEL-----KITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            ||:|.....:..|:||     |:.|....::  |......|...|.|..|...|  |..::..:|
Worm   133 TETEQTNTKSDAKSELNLGERKMRNMVIRRF--DGKFGIKGNLFPTIEALLANY--HVTNALETK 193

  Fly    73 IKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNK 137
            ..|.|:.|..:                                    :|..|:|    .::.:..
Worm   194 ENRFLKTPIDL------------------------------------QVWENRH----SAVKLGD 218

  Fly   138 QLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM---EFLKEAAIMHSIEHENIVRLYGV 199
            :||.|.:|.|::||....|:::.||:|.:  :..:.|.|   |.:.||.:|.:.:|:||||.:||
Worm   219 KLGEGAYGEVRKGVLHRKNKKLDVAVKLM--KGGELNKMKIREMMNEARLMRNFKHKNIVRFFGV 281

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            .:....|.::.||.:..:|...|:.:  :||.|.:..:|..|.|   |::||.....||||:|||
Worm   282 AVVEQPLYILLELVNGGALNTYLQKN--KVSDLELMRMCLGAAQ---GLQYLHANHCIHRDIAAR 341

  Fly   265 NILVFSKDK-VKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGV 328
            |.| :|.|| ||:||||||   .||..|   ......||||.|.|||.|....||..:||:::||
Worm   342 NCL-YSNDKVVKLSDFGLS---VVGNQY---KLCAAQKLPIKWLAPETITTRFFTPKTDVYSYGV 399

  Fly   329 CLWEMFSYGFQPWAALTGL----QILEAIDAPNYQRLEQPDCCPSEYYTLM-MKCWQDDAAKR-- 386
            ..:|:||.|.:||..:|..    .::..|:      |..|:.||.::.:.: .|.:..|..:|
Worm   400 MCFEIFSNGAEPWEGVTNTVTKNNVVNGIN------LVIPESCPEKFRSFVHEKIFVVDPKRRVV 458

  Fly   387 ----PRFGEIYDQLPDM-KPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGK 446
                .||  |...:.|| ....:..::|....|.|   |.|                       |
Worm   459 MDDVSRF--IEPIINDMHNAAAVSTMLNLASDKSD---YNQ-----------------------K 495

  Fly   447 TGYFNPSNTVAFL-EGLPSSTRDSFSRVSDHRISKRKLRT 485
            |...|.|..|..| ...|.:..:|..: :|:|   ||.||
Worm   496 TSDANRSMMVPNLTSSTPRNATNSMKQ-NDYR---RKTRT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	14/56 (25%)
		STYKc	133..396	CDD:214568	94/277 (34%)
		PTKc_Ack_like	137..398	CDD:270636	94/275 (34%)
		SH3	400..454	CDD:214620	8/53 (15%)
		CRIB	486..525	CDD:238077	137/495 (28%)
R11E3.1	NP_500644.2	SH2_Fps_family	73..191	CDD:198224	15/61 (25%)
		STYKc	214..466	CDD:214568	93/273 (34%)
		PTKc	218..467	CDD:270623	93/270 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910