DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and ver-4

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_509835.2	Gene:	ver-4 / 186632	WormBaseID:	WBGene00006897	Length:	1216	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	105/361 - (29%)
Similarity:	167/361 - (46%)	Gaps:	78/361 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQQG---VWSNGN----ERIQVAIKCLCRERMQSNPME--- 177
            |..:.|..:::.:.:.||:|:||||::|   :.|:.|    .|:.||||    ....|:.||
Worm   860 NEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIK----SSTDSSNMELQK 920

  Fly   178 -FLKEAAIMHSI-EHENIVRLYGVV---LATDSLMLVTEL---AHLRSLLECLKD--------SG 226
             |.:|..:|.:| :|.|::.|.|.|   :....|.:||||   .:||..|...:|        .|
Worm   921 MFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKG 985

  Fly   227 LRVSFLT-----IP---------------TLC-----EFALQICNGMRYLEQKRLIHRDLAARNI 266
              ..|||     :|               :||     ...|||.|||.:|.....:|||||.||:
Worm   986 --YIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNV 1048

  Fly   267 LVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLW 331
            |:.....::|:||||::. ...|.||:...:::..||:.|...|.|..|.||..||||::|:||:
Worm  1049 LISKTKIIRIADFGLAKK-HTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLY 1112

  Fly   332 EMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            |:|:.|..|:.......::|.|...|..:  :|..|..:.|.:|..|||.....||.|.|
Worm  1113 EIFTLGGTPYPDCPNFSLVEYIKTGNINK--RPSNCHKDVYKIMKMCWQASPDDRPTFAE----- 1170

  Fly   397 PDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRN 432
                         |.:..|:|:.|....::..::::
Worm  1171 -------------CIKLFKNHIQYFASKLLQQIEKD 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	99/313 (32%)
		PTKc_Ack_like	137..398	CDD:270636	99/311 (32%)
		SH3	400..454	CDD:214620	4/33 (12%)
		CRIB	486..525	CDD:238077
ver-4	NP_509835.2	ig	609..679	CDD:278476
		IG_like	611..692	CDD:214653
		IG_like	709..782	CDD:214653
		IGc2	714..772	CDD:197706
		STYKc	870..1175	CDD:214568	100/331 (30%)
		PTKc	874..1176	CDD:270623	100/328 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910