DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and sid-3

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_510783.2	Gene:	sid-3 / 181756	WormBaseID:	WBGene00002207	Length:	1237	Species:	Caenorhabditis elegans

Alignment Length:	1341	Identity:	304/1341 - (22%)
Similarity:	497/1341 - (37%)	Gaps:	368/1341 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLS 71
            ::.|.|.:::|..:.:.......:.....|.:..|:|:..||:.:.:||:||
Worm    12 NVLEVLRKAQLDAFISQFVFLFNVRRFDHFSHVRDKDMLEIGMQQVQIRQLR------------- 63

  Fly    72 KIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVN 136
              :::|:....|..|.:.    .||.:     .|..|:.|:|..       :.|.:||.:.|.:.
Worm    64 --EQILKMSREMWNRSDP----KQVYI-----QADQSMPAQNSI-------DEKALIPNEQIKLY 110

  Fly   137 KQLGTGEFGIVQQGVWSNGN-ERIQVAIKCLCRERMQSNPMEFLK-EAAIMHSIEHENIVRLYGV 199
            :.:|.|.|.:|::|.|:..| ..:.||:|.|  ..:..|.|:.|: ||:.:..::|.:::||||:
Worm   111 ELIGEGSFAVVKRGTWTQSNGTHVNVAVKIL--RDISPNIMDDLRVEASHLLKLQHPSLIRLYGI 173

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            |  ....|:|.||....|||:.|:|.  :.:.|.:..|.::.:||...:::||.|..:|||:|||
Worm   174 V--RQPAMMVFELCEGGSLLDRLRDD--KKAILLVSRLHDYCMQIAKALQFLESKHCVHRDVAAR 234

  Fly   265 NILVFSKDK-VKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGV 328
            |||:...:: |||.||||.|||...:..|  ......|:|.|||.||.:.:.:|::|||||::||
Worm   235 NILLARDERTVKICDFGLMRALKENEQMY--TMAPQKKVPFAWCPPEALRHRKFSHASDVWSYGV 297

  Fly   329 CLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIY 393
            .:||:|::|.:||.....:.:|:.|||.  :|||:|..|....|.:|..||:.:.|:|.:||.|.
Worm   298 TIWEVFTFGEEPWVGCRAIDVLKNIDAG--ERLEKPKYCSERIYQIMKNCWKFNPAERCKFGAIR 360

  Fly   394 DQLPDMKPEQLKAVV----NCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYF---- 450
            :.|  :....|.||.    |..:|  ..|...:||.:.|:: |||..::.......|.|.|
Worm   361 EDL--VAAMFLDAVARETYNSIQP--GALQLTKGDEVVVVE-NTGQDWFGQNKKNQKFGTFPRSV 420

  Fly   451 ---NPSNTVAF--------------------------LEGLPSSTRDSFSRVSDHRISKRKLRTE 486
               ..:|.||.                          |:.|.::|:.|.:.           ||.
Worm   421 VFAQTNNAVAAATAVTPQKVPTAPTIRIPPSHPPPAPLKPLNNNTKTSLND-----------RTS 474

  Fly   487 MISKP-QNDFKHTGHVG-IDGATFGDIAFLGSSQNYNHV----------------PKQIVT---- 529
            .||.| ...|.||||.. :.|.::|:.|.:......|.|                .|:::|
Worm   475 KISMPVAGSFIHTGHGDPLGGQSWGNPATIADMYLKNPVNGAPLSSMSSGAEIIASKELLTNGGR 539

  Fly   530 ----PYKPS----EDIEQTPLLLPPTPTSPDSLQTA--SGYFPE-----------------GANS 567
                |..||    ..|....|.||    ..|....|  .|:.|.                 |:||
Worm   540 STHQPAAPSPAVMSKIRGLSLDLP----EYDDFDRAFDDGFSPSKIELPREFCGNDSVISGGSNS 600

  Fly   568 GGAMGT-SMNP----------TFIPSAEHTPKLIATN-----------------GQSSFDFASGS 604
            .|...| .|.|          ..:|.....|.||.||                 ..||..|.|..
Worm   601 IGLANTYVMEPPKQAFDIRGNRVLPPTNKAPVLIPTNPAPSVISSTASAGITLSTNSSQMFTSQD 665

  Fly   605 TNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPS 669
            .:...|.....||:..|:...:.|..|      ||...|.:.       |.::::         |
Worm   666 RHSNMPANLFPELQHRLNQGSSTGNGV------RPRPASSIG-------IQNNDL---------S 708

  Fly   670 LLD-EINSMFGSIS-------------AATGSHPKSPGFDHVNNKNEITEMSAKLGQK--SGDTN 718
            :|: ::|..|..::             ..|.:.|....|....:...:.:......||  :.:..
Worm   709 MLNPQVNRPFSVVNVPIVQQPANIPCLVPTPAPPAPAHFSQPVSSQRVAQQQQNTLQKALNDELK 773

  Fly   719 GNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHSPKRKF 783
            ||         |:|:.:..|..|.:..:....:.|......||:.|:..|.......|..|.:..
Worm   774 GN---------LNKRPTGTTAPPSNGFNAPRADVAPVQQRPISSASIPALQPQPIQHIQKPIQPQ 829

  Fly   784 SFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKKNFTEELQSIPDIQRFRSLSEIKNST 848
            ..|.|        ..:..:........|||.|.:|....:...:....:|.    ::...:.|:.
Worm   830 QVRIP--------PSTAPVQKPVQVSAPTHSNVAPTTSSQASADARNPLPP----KTSPPVSNTP 882

  Fly   849 DLRVPIFDKESSDFLFQKSREILSRPLNLERECGDEQPPKSIDDNIMDIENTLKALNLDFMHTYT 913
            ....|:....::.  ...:..:..||.:...:..||:....|   .|||.:.
Worm   883 ITVAPVHAAPTTS--APSTSVVTRRPTSTTAQMSDEERRSRI---AMDISSA------------- 929

  Fly   914 ELDKSDSNDTILNDQLPHMASLDDGISSATGSLKSAVYSYSNGVQTMFDFNAATSHLDKHLQYMH 978
                           ||..::|..| |::|.||.||..|.::.|.:....|
Worm   930 ---------------LPAPSALLYG-SNSTSSLPSAAVSTASSVPSTARDN-------------- 964

  Fly   979 NQAQLSAAAPVDPKP------MDDKRSSTP--------DTGFASRDTNISLSRRSSQKSSY-SPQ 1028
                     ||:.:|      |..|:||.|        .|...|..|  |.::..:|...: ||.
Worm   965 ---------PVETRPSQPHVTMPPKKSSEPILSSEVLQPTRLPSATT--SQAKPVTQPIRHPSPP 1018

  Fly  1029 ESFHFPL-------------KGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIK 1080
            .:...|.             ...|||:.  ...|.||..|.   ||..:|||....
Worm  1019 VATVIPTAVVDKKPVSQNQGSNVPLFNI--TNSSNGYPQLN---GYPNYGNGFQAY--------- 1069

  Fly  1081 SGVGLNASSGSVYMGSKGYRQRSTSFNESFHPISPVLSEPPQRERGVIQRQVRLE-QQQPL---- 1140
             |.|:|...|  |.|.:||........:.....:.|.|.||     ::..:.|.. ..|||
Worm  1070 -GYGMNYHQG--YPGYQGYNSYGNGMGQLALTHNAVTSLPP-----LVPSENRFSGTAQPLGESD 1126

  Fly  1141 -------PRRSASYKPRSIRARTLRRLSYNPMTLDSSSSSG 1174
                   .:|.|....|::          .|.:..:|::||
Worm  1127 IMEFLGTQQRQAGSSSRAV----------PPASASTSAASG 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	12/57 (21%)
		STYKc	133..396	CDD:214568	98/265 (37%)
		PTKc_Ack_like	137..398	CDD:270636	98/263 (37%)
		SH3	400..454	CDD:214620	15/64 (23%)
		CRIB	486..525	CDD:238077	13/56 (23%)
sid-3	NP_510783.2	SAM_TNK-like	9..70	CDD:188938	13/72 (18%)
		STYKc	107..363	CDD:214568	98/265 (37%)
		PTKc_Ack_like	111..365	CDD:270636	98/265 (37%)
		SH3	371..421	CDD:214620	14/52 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910