DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and ver-3

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	103/354 - (29%)
Similarity:	159/354 - (44%)	Gaps:	77/354 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQQGVWS--------NGNERIQVAIKCLCRERMQSNPME-- 177
            ||.:.|...::.:...:|:|.||:|::|:..        ....|:.||:|      ..:||..
Worm   837 NNDYEIDPVNLEILNPIGSGHFGVVKKGLLGMAYPKSKIESKTRLPVAVK------SSTNPFNVE 895

  Fly   178 ----FLKEAAIMHSI-EHENIVRLYGVV---LATDSLMLVTEL---AHLRSLL---------ECL 222
                ..:|..:|.:| ::.|::.|.|.|   :....|.:|||.   .:||..|         |.:
Worm   896 LQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINELV 960

  Fly   223 KDSGLRV--SFLTIP--------------------------TLC-----EFALQICNGMRYLEQK 254
            :|..:.|  |:| :|                          .||     ...|||..||.:|...
Worm   961 EDEHVPVDDSYL-VPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADV 1024

  Fly   255 RLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            ..:|||||.||:|:.....|:|:|||||:. ...|.||:|..:.:..||:.|...|||...:||.
Worm  1025 PCVHRDLACRNVLITKTKIVRIADFGLSKK-HTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQ 1088

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            .||||:||:||:|:|:.|..|:.......::|.|  .|..|.:||:.|..|.|.||..|||.:..
Worm  1089 KSDVWSFGICLYEIFTLGGTPYPNCDTFNVIEFI--RNGNRNKQPEYCHDEIYELMKVCWQFNPK 1151

  Fly   385 KRPRFGE----IYDQLPDMKPEQLKAVVN 409
            .||.|.:    ..:.:.|...:.|:.|.|
Worm  1152 DRPTFNDCITFFENHMRDSSSQFLERVEN 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	96/329 (29%)
		PTKc_Ack_like	137..398	CDD:270636	96/327 (29%)
		SH3	400..454	CDD:214620	3/10 (30%)
		CRIB	486..525	CDD:238077
ver-3	NP_509836.1	IG	242..>313	CDD:214652
		IG_like	578..667	CDD:214653
		Ig_3	578..654	CDD:290638
		I-set	673..757	CDD:254352
		IGc2	692..747	CDD:197706
		STYKc	847..1163	CDD:214568	96/325 (30%)
		PTKc	851..1164	CDD:270623	96/322 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910