DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and abl-1

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:NP_509778.2 Gene:abl-1 / 181261 WormBaseID:WBGene00000018 Length:1224 Species:Caenorhabditis elegans


Alignment Length:1103 Identity:265/1103 - (24%)
Similarity:439/1103 - (39%) Gaps:235/1103 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 TESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLL 77
            :|:.:.||..:|:::.::.:   ::...|...:.......:.|.|.:....|..|:  ..:..||
 Worm   221 SETSIGQYTISVRHDGRVFH---YRINVDNTEKMFITQEVKFRTLGELVHHHSVHA--DGLICLL 280

  Fly    78 QAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTG 142
            ..|.:  |:::..|              ..||       ||: .|:...:..::.|..|| ||.|
 Worm   281 MYPAS--KKDKGRG--------------LFSL-------SPN-APDEWELDRSEIIMHNK-LGGG 320

  Fly   143 EFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPM-EFLKEAAIMHSIEHENIVRLYGVVLATDSL 206
            ::|.|.:|.|...:  ..:|:|.|..:.|   |: |||.|||||..:.|:|:|||.||.......
 Worm   321 QYGDVYEGYWKRHD--CTIAVKALKEDAM---PLHEFLAEAAIMKDLHHKNLVRLLGVCTHEAPF 380

  Fly   207 MLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSK 271
            .::||.....:|||.|:.:.  .|.|....|.:.|.||.:||.|||.:..|||||||||.||...
 Worm   381 YIITEFMCNGNLLEYLRRTD--KSLLPPIILVQMASQIASGMSYLEARHFIHRDLAARNCLVSEH 443

  Fly   272 DKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSY 336
            :.|||:||||:|.:  .:|.|..  :...|.||.|.|||.:.:..|::.||||||||.|||:.:|
 Worm   444 NIVKIADFGLARFM--KEDTYTA--HAGAKFPIKWTAPEGLAFNTFSSKSDVWAFGVLLWEIATY 504

  Fly   337 GFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIY-------- 393
            |..|:..:....:...::  |..|::.|..||...|.||::||....:.||||.:|:        
 Worm   505 GMAPYPGVELSNVYGLLE--NGFRMDGPQGCPPSVYRLMLQCWNWSPSDRPRFRDIHFNLENLIS 567

  Fly   394 -DQLPDMKPEQLKA--------------VVNCTEPKKDHLLY--RQGDIISVLDRNTG--TPFWK 439
             :.|.|...:|||.              |...::.|..|..:  |..|..|:..||:.  .|...
 Worm   568 SNSLNDEVQKQLKKNNDKKLESDKRRSNVRERSDSKSRHSSHHDRDRDRESLHSRNSNPEIPNRS 632

  Fly   440 GVLSTGKTGYFNPSNT---VAF-LEGLP--------------SSTRDSFSRVSDHRISKRKLRTE 486
            .:.:.....:||||.|   .:| .:|.|              .|..:|.:|.:.....:.:....
 Worm   633 FIRTDDSVSFFNPSTTSKVTSFRAQGPPFPPPPQQNTKPKLLKSVLNSNARHASEEFERNEQDDV 697

  Fly   487 MISKPQNDFKHTGHVG--------IDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQT--- 540
            :....:|..|....:|        ||       |:|.|.:.        |..:|.|.|.:..   
 Worm   698 VPLAEKNVRKAVTRLGGTMPKGQRID-------AYLDSMRR--------VDSWKESTDADNEGAG 747

  Fly   541 PLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNP------------TFIPSAEHTPKLIATN 593
            ...|..| .|.|||.|..  .|:..||  :....|:|            :.:.....||:|...:
 Worm   748 SSSLSRT-VSNDSLDTLP--LPDSMNS--STYVKMHPASGENVFLRQIRSKLKKRSETPELDHID 807

  Fly   594 GQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPT----SRSIVDDPHEYHEI 654
            ..::.:......:| |.:.....:::.:.| ..:....||.....|.    :.|:...|....|.
 Worm   808 SDTADETTKSEKSP-FGSLNKSSIKYPIKN-APEFSENHSRVSPVPVPPSRNASVSVRPDSKAED 870

  Fly   655 SDDEIAADKLDFGPSLLDEINSMFGSIS-AATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDTN 718
            |.||...|...:||.     :::...|. ....|:|...|           |:.||:       .
 Worm   871 SSDETTKDVGMWGPK-----HAVTRKIEIVKNDSYPNVEG-----------ELKAKI-------R 912

  Fly   719 GNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQ-TPVIHSPKRK 782
            ..:|    :|......||....|:...|.  .|.:|.:........:..||:.: :|:.|  .|.
 Worm   913 NLRH----VPKEESNTSSQEDLPLDATDN--TNDSIIVIPRDEKAKVRQLVTQKVSPLQH--HRP 969

  Fly   783 FSFRFPH------LSNNGSGDKSGGLGTSG------SAHTP---THGNASPFP--------KKKN 824
            ||.:.|:      :|::...|.|.....||      ....|   ::|:....|        |:.|
 Worm   970 FSLQCPNNSTSSAISHSEHADSSETSSLSGVYEERMKPELPRKRSNGDTKVVPVTWIINGEKEPN 1034

  Fly   825 FTEELQSIPDI-QRFRSL-------SEIKNSTDLRVPIFDKESSDFLF---QKSRE----ILSRP 874
            .....:|:.|| .:|..|       |:|:.:...|....:|:.:...|   :.|.|    :..|.
 Worm  1035 GMARTKSLRDITSKFEQLGTASTIESKIEEAVPYREHALEKKGTSKRFSMLEGSNELKHVVPPRK 1099

  Fly   875 LNLERECG--DEQPPKSIDDNIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQLPHMASLDD 937
            ...:.|.|  ||:|...  |.|:.:   ||.:..:|::.: .|..|:    |.:::|.....:.|
 Worm  1100 NRNQDESGSIDEEPVSK--DMIVSL---LKVIQKEFVNLF-NLASSE----ITDEKLQQFVIMAD 1154

  Fly   938 GISSATGSLKSAVYSYSNGVQTMFDFNAATSHLD---KHLQYMHNQAQLSAAAPVDPKPMDDK 997
            .:.....:  .:||:......:.|.|....|.|:   :.:::.||..         .||:|||
 Worm  1155 NVQKLHST--CSVYAEQISPHSKFRFKELLSQLEIYNRQIKFSHNPR---------AKPVDDK 1206

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938 7/51 (14%)
STYKc 133..396 CDD:214568 105/272 (39%)
PTKc_Ack_like 137..398 CDD:270636 104/270 (39%)
SH3 400..454 CDD:214620 15/71 (21%)
CRIB 486..525 CDD:238077 8/46 (17%)
abl-1NP_509778.2 SH3_Abl 119..185 CDD:212784
SH2_ABL 190..283 CDD:198189 11/66 (17%)
PTKc_Abl 304..566 CDD:270645 105/275 (38%)
Pkinase_Tyr 311..562 CDD:285015 105/264 (40%)
FABD 1091..1224 CDD:197885 29/137 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D539311at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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