DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and ark-1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001255654.1	Gene:	ark-1 / 178218	WormBaseID:	WBGene00000186	Length:	1043	Species:	Caenorhabditis elegans

Alignment Length:	1240	Identity:	353/1240 - (28%)
Similarity:	513/1240 - (41%)	Gaps:	335/1240 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |.:.|..::|..|.:.::.:||:.|||..:|..:.||..:|:||||.:||||.|.|.||.....|
Worm    14 LNKLLQAADLSGYESDLRRKLKLRNAADLQYVEEVDLLSVGMSRPEQKRLRKEYTKMFPSGIFGK 78

  Fly    73 IKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNK 137
            :|:..       ||.|                   ||..|...|..::..|:.|:||.:.|::.|
Worm    79 VKKAF-------KRAE-------------------SLDRKTSNSVANQDDNDHHVIPIEKITLCK 117

  Fly   138 QLGTGEFGIVQQGVWSN--GNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVV 200
            :||.||||.|.|..|.|  |::.||||:||:..:::.:....||:|||||..:.||::|||||||
Worm   118 ELGQGEFGSVWQAGWKNSAGSDVIQVAVKCVGSDKLLATSSSFLQEAAIMTRMRHEHVVRLYGVV 182

  Fly   201 LATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARN 265
            |.|..:|||:|||...||||||....||.|| .:..||::|.||..||.|||.:|||||||||||
Worm   183 LDTKKIMLVSELATCGSLLECLHKPALRDSF-PVHVLCDYAEQIAMGMSYLELQRLIHRDLAARN 246

  Fly   266 ILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCL 330
            :||||...||||||||||:||:|:|||::.|..|||||||||||||||:|:||:.|||||:||.:
Worm   247 VLVFSPKLVKISDFGLSRSLGIGEDYYRSEFTPNLKLPIAWCAPECINFLKFTSKSDVWAYGVTI 311

  Fly   331 WEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQ 395
            |||||||..||...:|.||||.:|... :.|.:|..||.:.|.::.:.|......||.|.:|..:
Worm   312 WEMFSYGEMPWKGRSGAQILELVDRKK-ELLTRPKACPEDIYDMLKETWTHQVQDRPTFSDIVAK 375

  Fly   396 LPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGT-P---FWKGVLSTGKTGYFNPSNTV 456
            .|:.:.:.::|||:|.:...|||.:::.|:|.|:.|:... |   :|.|.|..||.|.|.|::||
Worm   376 FPERRAQSVRAVVDCKDSAADHLHFKKDDLIVVISRSPAQYPDGYYWFGSLRNGKLGLFRPTDTV 440

  Fly   457 AFLEGLP----SSTRDSFSRVSD--------HRISKRKLRTEMISKPQNDFKHTGHVGIDGATFG 509
            |.|...|    .:..:.||....        .:.|:|:.:..:||:|..|.:||.||||||..||
Worm   441 AHLGSEPPCSNGTIENGFSEKEKGGKKNKKAEKESERERKKLLISEPVGDVRHTCHVGIDGTAFG 505

  Fly   510 DIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTS 574
            .:          .:.|:.:.                ||.:||                    .||
Worm   506 LL----------QLDKKAMC----------------PTSSSP--------------------STS 524

  Fly   575 MNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVH-SETGWR 638
            ......|:..||               |.||.                      .||| .||..|
Worm   525 RGSQASPAPSHT---------------SSSTT----------------------SSVHLRETVAR 552

  Fly   639 ---PTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNK 700
               |...::                 ...|.||...|.:| :..::|......|..|
Worm   553 NGVPIKETM-----------------SLRDVGPLSRDALN-LRDTVSPPVARAPSQP-------- 591

  Fly   701 NEITEMSAKLGQKSGDTNGNKHG---HGLLPTLSKKKSS--GTVKPISVKDEKILNHAIE-IANE 759
            ...::........|..::||:|.   |....:|.:.:.|  .|..|::......|...:. |:..
Worm   592 PSYSQPRPPPRSVSSVSSGNQHSVQVHDQFSSLDRSRGSLTPTAPPLTASAANSLKDPLTGISLS 656

  Fly   760 ISARSMIDLVSDQ-----------------TPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGS 807
            |.:.::|..:.||                 |....|..||.....|.             |...:
Worm   657 IPSNNLISYMDDQEDDHRWTRSPGAISQSTTLTALSSSRKDPIPAPR-------------GPVAA 708

  Fly   808 AHTPTHGNASPFPKKKNFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILS 872
            .:  ..|...|.|..|:.....:.|.|:.|..:...|....|.      .|....|...:|.|.|
Worm   709 VY--ARGKDIPTPASKSDIALCEKIEDLNRDLTNYSIGTICDY------SEDRPLLDSMNRTISS 765

  Fly   873 RPLNLERECGDEQPPKSIDDNIMDI-ENTLKALNLDFM--HTYT------ELDKSDSNDTILNDQ 928
            ...:       :.||:|.:..|..: |..::.:|....  |..|      |..|......|...|
Worm   766 STTH-------QPPPQSSEARIRFMTEQEVRKINEKSAREHRKTEDLLREERQKEQKPGEIEEPQ 823

  Fly   929 LPHMASL-------DDGISSAT-----------GSLKSAVYSYSNGVQTMFDFNAATSHLDKHLQ 975
            .| ..||       .:|.|||.           .:||.|    |.....|...::..|.||:
Worm   824 QP-AESLYSTRTPQQEGWSSAAQEAYKLLVECGTNLKQA----SVSPPPMSPTSSRLSTLDR--- 880

  Fly   976 YMHNQAQLSAAAPVDPKPMDDKRSSTPDTGFASRDTNISLSRRSSQK-------SSYSPQESFHF 1033
                    |:.:|..|:|:      ||.  .:.|:..||: |:|.|:       ...||:.....
Worm   881 --------SSISPAPPRPV------TPP--LSVRNETISM-RKSQQEEMEHVTVEENSPKRVHII 928

  Fly  1034 PLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIKSGVGLNASSGSVYMGSKG 1098
            ..|   |...|    :.|.:.::|            :.:.|..:|:.:|
Worm   929 ETK---LIDGP----ARGMSPIQD------------RHIPAFTTPMSNG---------------- 958

  Fly  1099 YRQRSTSFNESFHPISPVLSEPPQRERGVIQRQVRLEQQQPLPRRSASYKPRSIRARTLRRLSYN 1163
                  ||.::..| :||                     .|.|..|...||...|....|:.
Worm   959 ------SFRKAPAP-TPV---------------------SPAPAGSTDQKPPPCRPPKTRQF--- 992

  Fly  1164 PMTLD 1168
            |:.:|
Worm   993 PLVID 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	23/56 (41%)
		STYKc	133..396	CDD:214568	145/264 (55%)
		PTKc_Ack_like	137..398	CDD:270636	144/262 (55%)
		SH3	400..454	CDD:214620	20/57 (35%)
		CRIB	486..525	CDD:238077	14/38 (37%)
ark-1	NP_001255654.1	SAM_superfamily	14..71	CDD:301707	23/56 (41%)
		TyrKc	113..376	CDD:197581	145/264 (55%)
		PTKc_Ack_like	117..378	CDD:270636	144/262 (55%)
		SH3	384..434	CDD:214620	18/49 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165660
Domainoid	1	1.000	288	1.000	Domainoid score	I847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016809
OrthoInspector	1	1.000	-	-		oto18324
orthoMCL	1	0.900	-	-		OOG6_115700
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13625
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.840