DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and kin-16

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_496017.1	Gene:	kin-16 / 174499	WormBaseID:	WBGene00002200	Length:	495	Species:	Caenorhabditis elegans

Alignment Length:	369	Identity:	103/369 - (27%)
Similarity:	164/369 - (44%)	Gaps:	75/369 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 GASSPSKVPN-------------NKHIIPADSISVNKQLGTGEFGIVQQGVW---SNGNE----- 157
            |.:.|.::.|             .::.|.::::.....||:|.||:|::|:.   |..||
Worm   108 GDAMPEELKNRPLNDKLDYLPYKKQYEIASENLENKSILGSGNFGVVRKGILKMASPKNEEEKKM 172

  Fly   158 RIQVAIKCL--CRERMQSNPMEFLKEAAIMHSI-EHENIVRLYGVV---LATDSLMLVTELAHLR 216
            |:.||:|..  |.:..|::.:  ..|..:|.|| ...|::.|.|.|   |....|::|||.....
Worm   173 RLTVAVKSAANCYDISQTSML--AAELRLMCSIGRFPNVLALVGAVTSELRKGRLLIVTEYIDCG 235

  Fly   217 SLLECLKD-----------------------SGLRVSF-------------------LTIPTLCE 239
            .:.:.|.|                       |..|.::                   ||...|..
Worm   236 DIRKYLIDHRNVFQDHLIEDKTEPDSYLTPISAKRKNYVFKNTDENSDYVIKESLDSLTTSDLLS 300

  Fly   240 FALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPI 304
            |.|||.|||:||....::|||||.||:|:.....::|:|||::|. ...|.||......:..:|:
Worm   301 FGLQIANGMQYLASIPMVHRDLALRNVLLKKNKTIRIADFGMART-HENKSYYIPQKTKDAPVPV 364

  Fly   305 AWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPS 369
            .|.:||..:.::||..||||:||:||:|:|:.|..|:..:...:|.|.:.:.  :|..||..|..
Worm   365 RWMSPEAFDTMKFTEKSDVWSFGICLYEIFTLGQLPYPDVPSERIYEYMHSG--RRCPQPQHCHV 427

  Fly   370 EYYTLMMKCWQDDAAKRPRFGEIYDQ-LPDMKPEQLKAVVNCTE 412
            |.|.||..||.:....||.|....:. :..||....|.:.|..|
Worm   428 ELYDLMKLCWHEKPELRPNFSNCVEYFIGHMKKSASKLLENVDE 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	94/319 (29%)
		PTKc_Ack_like	137..398	CDD:270636	94/317 (30%)
		SH3	400..454	CDD:214620	4/13 (31%)
		CRIB	486..525	CDD:238077
kin-16	NP_496017.1	STYKc	140..454	CDD:214568	94/318 (30%)
kin-16	NP_496017.1	PTKc	145..454	CDD:270623	94/313 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910