DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Epha7

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_599158.1	Gene:	Epha7 / 171287	RGDID:	70957	Length:	998	Species:	Rattus norvegicus

Alignment Length:	358	Identity:	124/358 - (34%)
Similarity:	177/358 - (49%)	Gaps:	46/358 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            :.|..|.:.:.:|.||||.|..| :...|...:.||||.|.....:....:||.||:||...:|.
  Rat   628 LDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHP 692

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFL-------TIPTLCEFALQICNGMR 249
            |:|.|.|||.....:|:|.|          ..::|...:||       |:..|......|..|||
  Rat   693 NVVHLEGVVTRGKPVMIVIE----------FMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMR 747

  Fly   250 YLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YYKTNFNVNLKLPIAWCAPECIN 313
            ||.....:|||||||||||.|....|:|||||||.:....: .|.|...   |:|:.|.|||.|.
  Rat   748 YLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGG---KIPVRWTAPEAIQ 809

  Fly   314 YLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKC 378
            |.:||:|||||::|:.:||:.|||.:|:..::...:::||: ..| ||..|..||:..:.||:.|
  Rat   810 YRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIE-EGY-RLPAPMDCPAGLHQLMLDC 872

  Fly   379 WQDDAAKRPRFGEIYDQLPDM--KPEQLKAVV-NCTEPKKDHLLYRQGDIISVLDRNTGTPFWKG 440
            ||.:.|:||:|.:|...|..|  .|..||..: .|:.|           |..:||::  ||.:..
  Rat   873 WQKERAERPKFEQIVGILDKMIRNPSSLKTPLGTCSRP-----------ISPLLDQS--TPDFTA 924

  Fly   441 VLSTG------KTGYFNPSNTVAFLEGLPSSTR 467
            ..|.|      |...:..:.|.|....|.|..|
  Rat   925 FCSVGEWLQAIKMERYKDNFTAAGYNSLESVAR 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/271 (38%)
		PTKc_Ack_like	137..398	CDD:270636	103/269 (38%)
		SH3	400..454	CDD:214620	13/60 (22%)
		CRIB	486..525	CDD:238077
Epha7	NP_599158.1	EphR_LBD_A7	30..206	CDD:198453
		FN3	332..438	CDD:238020
		FN3	443..534	CDD:238020
		EphA2_TM	565..630	CDD:405290	0/1 (0%)
		PTKc_EphR_A	628..894	CDD:270651	105/280 (38%)
		SAM_EPH-A7	919..988	CDD:188947	10/39 (26%)
		PDZ-binding. /evidence=ECO:0000255	996..998
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910