DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Lyn

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001104566.1	Gene:	Lyn / 17096	MGIID:	96892	Length:	512	Species:	Mus musculus

Alignment Length:	405	Identity:	126/405 - (31%)
Similarity:	189/405 - (46%)	Gaps:	83/405 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 EKHFPHSYLSKI------------------KRLLQAPGT-----MVKREEAPGGGSQV------- 96
            |...|.:|::|:                  :|.|.|||.     :::..|...|...:
Mouse   110 EGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDP 174

  Fly    97 ------------ALDG-----------------------SSASACSSLAAKNGASSPSKVPNNKH 126
                        :||.                       .|...|..|.....:..|.| |.:|.
Mouse   175 MHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQK-PWDKD 238

  Fly   127 I--IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIE 189
            .  ||.:||.:.|:||.|:||.|..|.::|..   :||:|.|....|  :...||:||.:|.:::
Mouse   239 AWEIPRESIKLVKKLGAGQFGEVWMGYYNNST---KVAVKTLKPGTM--SVQAFLEEANLMKTLQ 298

  Fly   190 HENIVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQ 253
            |:.:||||.||...:.:.::||.....|||:.|| |.|.:|   .:|.|.:|:.||..||.|:|:
Mouse   299 HDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKV---LLPKLIDFSAQIAEGMAYIER 360

  Fly   254 KRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFT 318
            |..|||||.|.|:||......||:||||:|.: ...:|   ......|.||.|.|||.||:..||
Mouse   361 KNYIHRDLRAANVLVSESLMCKIADFGLARVI-EDNEY---TAREGAKFPIKWTAPEAINFGCFT 421

  Fly   319 NASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDA 383
            ..||||:||:.|:|:.:||..|:...|...::.|: :..| |:.:.:.||.|.|.:|..||::.|
Mouse   422 IKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSAL-SQGY-RMPRMENCPDELYDIMKMCWKEKA 484

  Fly   384 AKRPRFGEIYDQLPD 398
            .:||.|..:...|.|
Mouse   485 EERPTFDYLQSVLDD 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	1/2 (50%)
		STYKc	133..396	CDD:214568	101/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/261 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Lyn	NP_001104566.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		SH3_Lyn	67..122	CDD:212937	4/11 (36%)
		SH2_Src_Lyn	125..225	CDD:198227	12/99 (12%)
		PTKc_Lyn	239..510	CDD:270657	106/275 (39%)
		Pkinase_Tyr	247..497	CDD:285015	101/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010