DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Frk

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001153016.1	Gene:	Frk / 14302	MGIID:	103265	Length:	512	Species:	Mus musculus

Alignment Length:	273	Identity:	107/273 - (39%)
Similarity:	170/273 - (62%)	Gaps:	14/273 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..:||.:.|:||:|:||.|.:|:|:|   ...||:|.|....|  :|.:||:||.||.|:.|..
Mouse   236 IDRNSIQLLKRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGSM--DPNDFLREAQIMKSLRHPK 295

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            :::||.|....|.:.::|||....||.|.|: |.|.::..:   ...:.|.|:.:||.|||.:..
Mouse   296 LIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDGGSKIHLI---QQVDMAAQVASGMAYLESQNY 357

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGV-GKDYYKTNFNVNLKLPIAWCAPECINYLRFTNA 320
            |||||||||:||...:..|::||||:|...| .:|.|::...:  |||:.|.|||.|...:|:..
Mouse   358 IHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESKHEI--KLPVKWTAPEAIRTNKFSIK 420

  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAK 385
            ||||:||:.|:|:.:||..|::.:||.|:::.: :.|| ||.||..||.::|::|::||..:..:
Mouse   421 SDVWSFGILLYEIITYGKMPYSGMTGAQVIQML-SQNY-RLPQPSNCPQQFYSIMLECWNVEPKQ 483

  Fly   386 RPRFGEIYDQLPD 398
            ||.|..::.:|.|
Mouse   484 RPTFETLHWKLED 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	103/264 (39%)
		PTKc_Ack_like	137..398	CDD:270636	103/262 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
Frk	NP_001153016.1	SH3_Src_like	54..111	CDD:212779
		SH2_Src_Frk	119..214	CDD:199831
		PTKc_Frk_like	232..501	CDD:270653	107/273 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920