DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and ptk2ab

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_021322273.1	Gene:	ptk2ab / 142986	ZFINID:	ZDB-GENE-020114-1	Length:	1142	Species:	Danio rerio

Alignment Length:	652	Identity:	182/652 - (27%)
Similarity:	267/652 - (40%)	Gaps:	161/652 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVW-SNGNERIQVAIKCLCRERMQSNPME-FLKEAAIMHSIEH 190
            |..|.|.:.:.:|.|:||.|.||:: ......:.|||| .|:.....:..| ||:||..|...:|
Zfish   473 IQRDRIELGRCIGEGQFGDVHQGIYICPDTPALSVAIK-TCKNCTSDSVREKFLQEALTMRQFDH 536

  Fly   191 ENIVRLYGVVLATDS----LMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYL 251
            .:||:|.||:  |::    :|.:..|..|||.|:      :|...|.:.:|..|:.|:...:.||
Zfish   537 PHIVKLIGVI--TENPVWIIMELCTLGELRSFLQ------IRKYNLDLASLILFSYQLSTALAYL 593

  Fly   252 EQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLR 316
            |.||.:|||:||||:||.|.|.||:.||||||.: ....|||.:..   ||||.|.|||.||:.|
Zfish   594 ESKRFVHRDIAARNVLVSSVDCVKLGDFGLSRYM-EDSSYYKASKG---KLPIKWMAPESINFRR 654

  Fly   317 FTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQD 381
            ||:|||||.||||:||:..||.:|:..:....::..|:  |.:||..|..||...|:||.|||..
Zfish   655 FTSASDVWMFGVCMWEILMYGVKPFQGVKNNDVIGRIE--NGERLAMPPNCPPTLYSLMTKCWAY 717

  Fly   382 DAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGT----------- 435
            |.:|||||.|:..||..:..|: ||.   .|.:....:.||   :.|...:.|:
Zfish   718 DPSKRPRFTELKGQLSTILAEE-KAQ---QEERSRMEMRRQ---VPVSWDSGGSDEAPPKGPRTR 775

  Fly   436 ----------PFWKGV----LSTGKTGYFNPSNTVAFLEGLPS-STRDSFSRVSDHRISKRKLRT 485
                      |::..:    ||.....:..||.     .|.|| .:.:.|.....|
Zfish   776 PSVPPGIFFDPYYPSMQQLSLSHAPYRFTQPSR-----PGYPSPRSSEGFYPSPQH--------- 826

  Fly   486 EMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTS 550
               ....|.::..||.|..|        |.|.....:.|:..||...|.:......:       :
Zfish   827 ---MGQHNHYQMAGHSGPHG--------LLSVPGGLYPPQATVTGLDPHDSWNHRRV-------A 873

  Fly   551 PDSLQTASGYFPEGANSGGAMGTSMNPTFIPS----------AEHTPKLIATNGQSSFDFASGST 605
            .|.:...|  ..:|....|.:...|....|..          .||..:|:..:|:||    .|||
Zfish   874 QDHMWNPS--MEDGVALRGGLSQLMEEQLILQQQQMEDDQRWLEHEERLLKPDGRSS----RGST 932

  Fly   606 NPFFPNRGDDELE---FGLHNYGADGKSVHSETGWRP---------TSRSIVDDPHEYHE----- 653
                 .|.|..|:   ...|.|...||:.|:....:|         ...|.::....|:|
Zfish   933 -----ERDDGSLQGPTGNQHIYQPIGKAEHAAPPKKPPRPGAPSHAAGVSGLNPTESYNEGVKPW 992

  Fly   654 -ISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNK---------NEITEMSA 708
             |...||                           :.|.:...|..|:|         ..:.|||:
Zfish   993 RIQPQEI---------------------------NPPPTANLDRSNDKVYENVTGLVKAVIEMSS 1030

  Fly   709 KL 710
            |:
Zfish  1031 KI 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	111/268 (41%)
		PTKc_Ack_like	137..398	CDD:270636	112/266 (42%)
		SH3	400..454	CDD:214620	12/78 (15%)
		CRIB	486..525	CDD:238077	7/38 (18%)
ptk2ab	XP_021322273.1	B41	74..296	CDD:214604
		FERM_C_FAK1	292..396	CDD:270011
		PTKc_FAK	471..740	CDD:133187	116/282 (41%)
		Focal_AT	1006..1134	CDD:308942	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910