DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Fgr

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_034338.3	Gene:	Fgr / 14191	MGIID:	95527	Length:	517	Species:	Mus musculus

Alignment Length:	322	Identity:	114/322 - (35%)
Similarity:	164/322 - (50%)	Gaps:	31/322 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CSSLAAKNGASSPSKVPNNKHI--IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCR 168
            |..|.|....:.|..:...|..  |..:||::.::||||.||.|..|.|   |...:||:|.|..
Mouse   222 CYLLTAPCTTTKPQTLGLAKDAWEIDRNSIALERRLGTGCFGDVWLGTW---NCSTKVAVKTLKP 283

  Fly   169 ERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKD-SGLRVSFL 232
            ..|  :|..||:||.||..:.|:.:|:||.|| :.:.:.:|||.....|||:.||| .|..   |
Mouse   284 GTM--SPKAFLEEAQIMKLLRHDKLVQLYAVV-SEEPIYIVTEFMCYGSLLDFLKDREGQN---L 342

  Fly   233 TIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFN 297
            .:|.|.:.|.|:..||.|:|:...|||||.|.||||......||:||||:|.: ...:|   |..
Mouse   343 MLPHLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEYLICKIADFGLARLI-EDNEY---NPQ 403

  Fly   298 VNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLE 362
            ...|.||.|.|||...:.|||..||||:||:.|.|:.:.|..|:..:...::||.::  :...:.
Mouse   404 QGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVE--HGYHMP 466

  Fly   363 QPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGD 424
            .|..||:..|.:|.:.|:.|..:||.|..:...|.|        ....|||:     |:.||
Mouse   467 CPPGCPASLYEVMEQAWRLDPEERPTFEYLQSFLED--------YFTSTEPQ-----YQPGD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	99/263 (38%)
		PTKc_Ack_like	137..398	CDD:270636	99/261 (38%)
		SH3	400..454	CDD:214620	6/25 (24%)
		CRIB	486..525	CDD:238077
Fgr	NP_034338.3	SH3	68..125	CDD:388381
		Interaction with CLNK. /evidence=ECO:0000269\|PubMed:16439675	102..103
		SH2_Src_Fgr	128..228	CDD:198230	2/5 (40%)
		PKc_like	255..502	CDD:389743	99/261 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010