DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Epha5

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_006534832.1	Gene:	Epha5 / 13839	MGIID:	99654	Length:	1040	Species:	Mus musculus

Alignment Length:	440	Identity:	137/440 - (31%)
Similarity:	207/440 - (47%)	Gaps:	61/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GSSASACS----SLAAKNGASSPSKVP-------NNKHI-------------------------- 127
            |.::|.|:    ||..:.|.|...:.|       :|.||
Mouse   607 GRASSLCAVAHPSLIWRCGYSKAKQDPEEEKMHFHNGHIKLPGVRTYIDPHTYEDPNQAVHEFAK 671

  Fly   128 -IPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEH 190
             |.|..|::.:.:|.||||.|..| :...|...:.||||.|.....:....:||.||:||...:|
Mouse   672 EIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDH 736

  Fly   191 ENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKR 255
            .||:.|.|||..:..:|:|||.....||...||.:.   ...|:..|......|..||:||....
Mouse   737 PNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKND---GQFTVIQLVGMLRGIAAGMKYLSDMG 798

  Fly   256 LIHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YYKTNFNVNLKLPIAWCAPECINYLRFTN 319
            .:||||||||||:.|....|:|||||||.|....: .|.|...   |:||.|.|||.|.:.:||:
Mouse   799 YVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGG---KIPIRWTAPEAIAFRKFTS 860

  Fly   320 ASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAA 384
            :||||::|:.:||:.|||.:|:..:|...:::|:: ..| ||..|..||:..|.||:.|||.|..
Mouse   861 SSDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE-EGY-RLPSPMDCPAALYQLMLDCWQKDRN 923

  Fly   385 KRPRFGEIYDQLPDM--KPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKT 447
            .||:|.||.:.|..:  .|..||.:||.:. :...||...|.:.|...|:.|.  |...:..|:.
Mouse   924 SRPKFDEIVNMLDKLIRNPSSLKTLVNASS-RVSTLLAEHGSLGSGAYRSVGE--WLEAIKMGRY 985

  Fly   448 GYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRK--------LRTEMIS 489
            ......|..:.::.:...|.:...|:....:..:|        ::.:|::
Mouse   986 TEIFMENGYSSMDAVAQVTLEDLRRLGVTLVGHQKKIMSSLQEMKVQMVN 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	105/264 (40%)
		PTKc_Ack_like	137..398	CDD:270636	105/262 (40%)
		SH3	400..454	CDD:214620	13/53 (25%)
		CRIB	486..525	CDD:238077	1/4 (25%)
Epha5	XP_006534832.1	EphR_LBD	62..234	CDD:383093
		FN3	360..466	CDD:238020
		FN3	471..561	CDD:238020
		EphA2_TM	581..673	CDD:373140	11/65 (17%)
		PTKc_EphR_A	673..939	CDD:270651	108/273 (40%)
		SAM_EPH-A5	968..1033	CDD:188945	8/66 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910