DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and Epha3

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_034270.1	Gene:	Epha3 / 13837	MGIID:	99612	Length:	984	Species:	Mus musculus

Alignment Length:	450	Identity:	141/450 - (31%)
Similarity:	210/450 - (46%)	Gaps:	75/450 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGS 101
            |::|:|.....|....::..||.:.:   ||:|                  |.|
Mouse   574 KHSAEEKRLHFGNGHLKLPGLRTYVD---PHTY------------------EDP----------- 606

  Fly   102 SASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKC 165
             ..|....|.:               :.|.:||::|.:|.||||.|..| :.....:.|.||||.
Mouse   607 -TQAVHEFAKE---------------LDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKT 655

  Fly   166 LCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRV- 229
            |.....:....:||.||:||...:|.||:||.|||..:..:|:|||.....||     ||.||.
Mouse   656 LKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSL-----DSFLRKH 715

  Fly   230 -SFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YY 292
             :..|:..|......|.:||:||.....:||||||||||:.|....|:|||||||.|....: .|
Mouse   716 DAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 780

  Fly   293 KTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPN 357
            .|...   |:||.|.:||.|.|.:||:|||||::|:.|||:.|||.:|:..::...:::|:| ..
Mouse   781 TTRGG---KIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVD-EG 841

  Fly   358 YQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDM--KPEQLKAVVNCTEPKKDHLLY 420
            | ||..|..||:..|.||:.|||.|...||:|.:|...|..:  .|..|| ::.....:..:||.
Mouse   842 Y-RLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNPGSLK-IITSAAARPSNLLL 904

  Fly   421 RQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISK 480
            .|.::.......||.  |...:.|        ::......|:..|:.|:.:::|...:.|
Mouse   905 DQSNVDIATFHTTGD--WLNGMRT--------AHCKEIFTGVEYSSCDTIAKISTDDMKK 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	6/27 (22%)
		STYKc	133..396	CDD:214568	111/266 (42%)
		PTKc_Ack_like	137..398	CDD:270636	110/264 (42%)
		SH3	400..454	CDD:214620	10/53 (19%)
		CRIB	486..525	CDD:238077
Epha3	NP_034270.1	EphR_LBD_A3	29..201	CDD:198449
		fn3	327..417	CDD:278470
		FN3	437..528	CDD:238020
		EphA2_TM	<566..617	CDD:291255	13/90 (14%)
		PTKc_EphR_A	617..883	CDD:270651	113/275 (41%)
		Pkinase_Tyr	622..879	CDD:285015	111/266 (42%)
		SAM	909..976	CDD:197735	8/55 (15%)
		SAM_EPH-A3	913..975	CDD:188943	8/51 (16%)
		PDZ-binding. /evidence=ECO:0000255	982..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910