Protein Alignment Ack-like and AgaP_AGAP011776

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: XP_320737.4
• Gene: AgaP_AGAP011776 / 1280867
• VectorBaseID: AGAP011776
• Length: 1082
• Species: Anopheles gambiae
• Alignment Length: 1321
• Identity: 322/1321 - (24%)
• Similarity: 496/1321 - (37%)
• Gaps: 388/1321 - (29%)

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRLRKFYEKHFPHSYLSK 72
            |.|.|.:.:|:|:...:::||::|..|.|.|...:||..|||.:|.||||.:..:|.....:...
Mosquito     9 LEELLKDVQLEQFLPRIRDELQVTRLAHFDYVHVDDLEKIGLGKPGIRRLLEAVKKRKAQQWRRN 73

  Fly    73 IKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNK 137
            |...|...|.....:::.|.|..|...|.:... |:||.             ..:|....::::.
Mosquito    74 ILSKLIGGGKQQPPKKSTGVGGSVGGAGQNEEP-SALAL-------------TCLIHEKDVTLSV 124

  Fly   138 QLGTGEFGIVQQGVW-SNGNERIQVAIKCLCRERM-QSNPME-FLKEAAIMHSIEHENIVRLYGV 199
            :||.|.||:|::|.| :.||..:.||:|.|..:.: |...:| |.||...||::.|.|::||:||
Mosquito   125 KLGDGSFGVVRRGEWHAPGNHLVPVAVKVLKADTLAQPGVIEDFFKEVQAMHAMNHPNLIRLHGV 189

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            || :..:|:|||||...|||:.|:.   :.....:|.:..:::||..||.|||.||.:|||||.|
Mosquito   190 VL-SQPMMMVTELAVNGSLLDLLRK---QCKHTPLPMIWSWSVQIATGMAYLESKRFLHRDLACR 250

  Fly   265 NILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVC 329
            |:|:.:.:|:||.||||.|||...:|.|.  ...:.|:|..|||||.:.|.:|::|||.|.|.|.
Mosquito   251 NVLLAAGNKIKIGDFGLMRALPQQEDCYV--MTEHKKVPFPWCAPESLRYRQFSHASDTWMFAVT 313

  Fly   330 LWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYD 394
            |||||::|..||..|.|.|||..||... :||..||.||.:.|.||::||....::||.|..|.:
Mosquito   314 LWEMFTFGEDPWVGLNGSQILRKIDREG-ERLHHPDACPPDVYQLMLQCWDKTPSERPTFAAIKE 377

  Fly   395 QLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFL 459
            .|..:.|...:||.|.:  .::.|..:|||.|.::|......|.||            .|...|.
Mosquito   378 FLTGVPPPIYRAVSNYS--AENRLAAQQGDTIVIVDDRPELQFIKG------------QNQRTFD 428

  Fly   460 EG-LPSSTRDSFSRVSDHRISKRKLRTEMISKPQND-FKHTGH---------------VGID--G 505
            .| :||:|                     ||:|.:| |:||||               |.:|  |
Mosquito   429 IGTIPSAT---------------------ISRPLHDSFRHTGHGNSTLNFLLDKSKDLVSVDRRG 472

  Fly   506 ATFGDIAFL------GSSQ-------NYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTA 557
            ....: .::      .|.|       |.||..:|.:.        .|..|..||.|..|......
Mosquito   473 KCISE-QYVKERKSNASKQFSYNKLVNENHSKQQHLH--------HQAQLHRPPRPPQPQQPAAT 528

  Fly   558 SGYF------PEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDE 616
            .|..      .:.|..||:.|.|      .:|..|.:.:|:......|         .|..|||.
Mosquito   529 EGILIDLSSPNDDATFGGSSGAS------GAAPGTVRQVASILDEPID---------IPTEGDDP 578

  Fly   617 LEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHE-----------YHEISDDEIAADKLD----- 665
                   :||.          :|..:.     ||           :..:|.....|.||:
Mosquito   579 -------FGAQ----------QPAQQQ-----HEQQHLQLATVASFASVSPVPSVAAKLEPPPYQ 621

  Fly   666 -----------FGPSLLDEINSMFGSISAAT-----GSHPKSPGFDHVNNKNEITEMSAKLGQKS 714
                       .|||.......:..||....     .:.|..|.:.  |.:..::.:::..|:..
Mosquito   622 MPPKYSNTYGISGPSSSVSARDLMASIKRQQTIEQGAAPPTQPVYG--NWRGSVSNINSNYGRVG 684

  Fly   715 GDTNGNKHGHGLLPTLSKKKS-SGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPVIHS 778
            .|.:|..  ..:|.:|:...| ||...|...:|  ..|.::|:
Mosquito   685 TDLDGLT--ADMLSSLNNGASGSGLSSPGGSRD--TYNDSLEV---------------------- 723

  Fly   779 PKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPFPKKKNFTEELQSIPDIQRFRSLSE 843
                      ::|.|......||        :..|.|.:|....|:|..||:.  ||  ::....
Mosquito   724 ----------NVSGNELASPYGG--------STAHVNVTPKKLDKSFLAELEK--DI--YKQEPS 766

  Fly   844 IKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLERECGDEQPPKSIDDNIMDIENTLKALNLDF 908
            ..||.:..|....:.|:                           |.:..:..|     ...||..
Mosquito   767 AGNSMNSSVAYAARNSA---------------------------KDVSHSKYD-----TTANLAM 799

  Fly   909 MHTYTELDKSDSNDTILNDQL---PHMASL-DDGISSATGSLKSAVYSYSNGVQTMFDFNAATSH 969
            ...|.....|.:....|..||   |...:: ...::|.|.:|...:::..|
Mosquito   800 SQIYANQANSIALAASLQQQLTLSPKKQNMVQQPVASDTNTLVQQMWAERN-------------- 850

  Fly   970 LDKHLQYMHNQAQLSAAAPVDPKPMDDKRSSTPDTGFASRDTNISLSRRSSQKSSYSPQESFHF- 1033
                     |.|..:||||:            ||.|                :...|||:|.:|
Mosquito   851 ---------NVAAAAAAAPL------------PDGG----------------QQPVSPQKSHNFV 878

  Fly  1034 ------------------PLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIK 1080
                              .|.|..::|:   |.:|..|| .|.  |:..|.    .:....:|..
Mosquito   879 ALSNGVQPAHHHQYGSTMSLSGANIYSS---VYNGSIAS-SDV--YQTVGG----DLYDVVAPTP 933

  Fly  1081 SGVGLNASSGSVY---MGSKG---------------YRQRSTSFNESFHPISPVLSEPPQRERGV 1127
            :.:.....:..:|   ||.:|               |.:.|........||.|..|.|...::
Mosquito   934 ASLYERVPAQQIYNNVMGQQGSMMAINITGPNATAIYDEVSNEQLSELRPIRPAPSAPLSAQQ-- 996

  Fly  1128 IQRQV-RLEQQQPLPRRSASYKPRSIRARTLRRLSYNPMTLDSSSSSGEEPVKPSLARSECDIRA 1191
            |||:: ||.||.   ::.||                  :..:....:.||..:.|||....|
Mosquito   997 IQRRLDRLAQQD---QQVAS------------------LLQELGDEANEEEARNSLAAVNWD--- 1037

  Fly  1192 RVAASSNSSLGRRRRAGM-NR 1211
            ...|..:..:.|..|.|: ||
Mosquito  1038 HTLAVRHFKIERLCRLGLANR 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	22/56 (39%)
		STYKc	133..396	CDD:214568	114/265 (43%)
		PTKc_Ack_like	137..398	CDD:270636	115/263 (44%)
		SH3	400..454	CDD:214620	13/53 (25%)
		CRIB	486..525	CDD:238077	17/69 (25%)
AgaP_AGAP011776	XP_320737.4	SAM_TNK-like	5..66	CDD:188938	22/56 (39%)
		Pkinase_Tyr	120..379	CDD:285015	114/265 (43%)
		PTKc_Ack_like	125..380	CDD:270636	114/261 (44%)
		UBA_TNK1	1041..1080	CDD:270513	6/18 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820