DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and AgaP_AGAP012070

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_320455.4	Gene:	AgaP_AGAP012070 / 1280600	VectorBaseID:	AGAP012070	Length:	1411	Species:	Anopheles gambiae

Alignment Length:	654	Identity:	168/654 - (25%)
Similarity:	247/654 - (37%)	Gaps:	160/654 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGN---ERIQVAIKCLCRERMQSN 174
            ||......:|.    :..:|:.:.|.||.|.||.|.||::.:.:   ..:.||:|.|........
Mosquito   885 NGNVDVKSLPQ----VARESLRLVKALGQGAFGEVYQGLYRHRDGDAVEMPVAVKTLPEMSTGQA 945

  Fly   175 PMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTEL---AHLRSLLECLKDSGLRVSFLTIPT 236
            ..:||.|||||....|.|||.|.||........:|.||   ..|::.|...::...|.|.||:..
Mosquito   946 ESDFLMEAAIMAKFNHPNIVHLIGVCFDRHPRFIVLELLAGGDLKNFLREGRNKPERPSPLTMKD 1010

  Fly   237 LCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDK---VKISDFGLSRALGVGKDYYKTNFNV 298
            |...||.:..|.||:|.||.||||:||||.|:.||..   |||:|||::|.: ...|||:.....
Mosquito  1011 LIFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMARDI-YRSDYYRKGGKA 1074

  Fly   299 NLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQ 363
              .|||.|..||......||:.:|||:|||.|||:||.|..|:..|....:::.:....  ||:.
Mosquito  1075 --MLPIKWMPPEAFLDGIFTSKTDVWSFGVLLWEVFSLGLMPYTGLPNRDVMQLVTGGG--RLDA 1135

  Fly   364 PDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISV 428
            |..||...|.:|.:||.....:||.|..:.:            |..||:..:
Mosquito  1136 PQGCPMAVYRIMAECWNPTPEERPTFSNLLE------------VTTCTQDPE------------- 1175

  Fly   429 LDRNTGTPFWKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQN 493
                        |::.....:|.|          ||:.||                |.::..|.|
Mosquito  1176 ------------VMNAPLPSFFRP----------PSNERD----------------TTIMRPPGN 1202

  Fly   494 DFKHTGHVGIDGATFGDIAF-LGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTA 557
            |               |... :.:|.:|       :.|......:.:..|......|.||:|.|.
Mosquito  1203 D---------------DFCLQVPNSSDY-------LIPLPGPRSVAERLLSEATGVTIPDTLMTC 1245

  Fly   558 SGYFPEGANSGGAMGTSMNPTFIPSAEHTPKLIATNGQS---SFDFASGSTNPFFPNRGDDELEF 619
            :                      |....:|:::  ||.:   |...|..:..|..|....|..|.
Mosquito  1246 T----------------------PPKNASPRIM--NGHTVVVSNALACPAGVPLPPPPVLDPAEA 1286

  Fly   620 GLHNYGADGKSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLD-EINSMFGSIS- 682
            .|                .|...|:|..| ...|::|..|:.|.....|:.:. .|:|:...|:
Mosquito  1287 VL----------------PPNGPSMVPPP-PVPEVADKLISLDTPQQTPTAIQPPISSIPPPITL 1334

  Fly   683 --AATG---SHPKSPGFDHVNNKNEITEMSAKLGQK-SGDTNG---NKHG-HGLLPTLSKKKSSG 737
              ||..   :|.....:.::...|......|..|.. |...||   |.|| ||..|...:..|..
Mosquito  1335 DPAALSMQQNHVVGTSYANIRMMNSANGNGAGGGHNHSSSNNGNNNNNHGDHGAAPFTIQTFSER 1399

  Fly   738 TVKP 741
            .:.|
Mosquito  1400 YISP 1403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	100/271 (37%)
		PTKc_Ack_like	137..398	CDD:270636	100/269 (37%)
		SH3	400..454	CDD:214620	6/53 (11%)
		CRIB	486..525	CDD:238077	6/39 (15%)
AgaP_AGAP012070	XP_320455.4	MAM	12..176	CDD:279023
		MAM	12..173	CDD:99706
		MAM	231..415	CDD:279023
		MAM	231..413	CDD:99706
		PTKc_ALK_LTK	894..1166	CDD:270632	102/280 (36%)
		Pkinase_Tyr	901..1166	CDD:285015	100/269 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910