DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and AgaP_AGAP003986

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_003436676.1	Gene:	AgaP_AGAP003986 / 1278803	VectorBaseID:	AGAP003986	Length:	1143	Species:	Anopheles gambiae

Alignment Length:	281	Identity:	99/281 - (35%)
Similarity:	155/281 - (55%)	Gaps:	18/281 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..:.:.:.:.:|.||||.|..|:....    :||:|.|......||  :||.||.:|.::||||
Mosquito   880 IKMEDLQLKENIGKGEFGDVMLGIMKGE----KVAVKVLKDAGRASN--KFLAEAGVMTTLEHEN 938

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|:..|:|.....:.||||.....||::.|:..|.:  .::......||...|.||.|||.|::|
Mosquito   939 LVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQ--HISRKDQINFAYDTCCGMEYLETKKVI 1001

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||||||:|:......|:|||||:|     .:.|..:   :.||||.|.|||.:...:|:|.:|
Mosquito  1002 HRDLAARNVLISEDCVAKVSDFGLAR-----DERYTGD---SSKLPIKWTAPEALKEGKFSNKTD 1058

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            :|:||:.|||::|:|..|:..:....:::.:.: .| ::|.|:.||.|.|.:|.:.|.....|||
Mosquito  1059 MWSFGILLWEIYSFGRVPYPRIPLADVVKHVGS-GY-KMEAPEGCPPEIYEMMRQAWDLVPEKRP 1121

  Fly   388 RFGEIYDQLPDMKPEQLKAVV 408
            .|.|:..:|.:.|.|.....|
Mosquito  1122 TFAELKRRLYNCKRETANTYV 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	94/262 (36%)
		PTKc_Ack_like	137..398	CDD:270636	95/260 (37%)
		SH3	400..454	CDD:214620	3/9 (33%)
		CRIB	486..525	CDD:238077
AgaP_AGAP003986	XP_003436676.1	SH2_csk_like	770..866	CDD:198190
		PTKc_Csk_like	878..1132	CDD:270635	96/269 (36%)
		STYKc	885..1130	CDD:214568	94/262 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920