DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and AgaP_AGAP008317

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_317149.4	Gene:	AgaP_AGAP008317 / 1277670	VectorBaseID:	AGAP008317	Length:	599	Species:	Anopheles gambiae

Alignment Length:	443	Identity:	130/443 - (29%)
Similarity:	201/443 - (45%)	Gaps:	89/443 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLR-------FIG-LSRPEIRRLRKFYEK-- 63
            ||.:.:|  |:::..||::..........|..:::|.       ::| :||.....|.|..:|
Mosquito   182 YEVIDDS--QEHWWKVKDQHGTIGYIPSNYVKEKELLGLQKYDWYVGDMSRQRAESLLKQNDKEG 244

  Fly    64 ------------------------HFPH----------SYLSKIKRLLQAPGTMVKREEAPGGGS 94
                                    |..|          .|||: |...:....::.......||.
Mosquito   245 CFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARSEFYLSE-KHCCETIPDLINYHRHNSGGL 308

  Fly    95 QVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERI 159
            ...|   ..|.|..........|     ::|..|....:.:.::||:|:||:|::..|...   |
Mosquito   309 ACRL---KTSPCDRPVPPTAGLS-----HDKWEIHPSELMILEELGSGQFGVVRRAKWRGS---I 362

  Fly   160 QVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK- 223
            ..|:|.:....|..:  :|::||.:|..::|.|:|:||||......:.::||.....|||..|:
Mosquito   363 DTAVKMMKVGTMSED--DFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIITEYMKHGSLLNYLRR 425

  Fly   224 -------DSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGL 281
                   :.||         |.:..:|:|.||.|||:...|||||||||.||.|::.||::||||
Mosquito   426 HEQSLIGNMGL---------LLDMCIQVCKGMSYLERHNYIHRDLAARNCLVGSENTVKVADFGL 481

  Fly   282 SRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTG 346
            :|.  |..|.|.::...  |.||.|..||.:||.||::.|||||:||.:||:|:.|..|:..|..
Mosquito   482 ARY--VLDDQYTSSGGT--KFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEVFTCGKMPYGRLKN 542

  Fly   347 LQILEAIDAPNYQR---LEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQL 396
            .:::|.:     ||   ||:|..|..|.|.:|.|||......||.|..:.|||
Mosquito   543 TEVVERV-----QRGIILEKPKACAKEIYDVMKKCWSHSPEDRPGFRILKDQL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	14/89 (16%)
		STYKc	133..396	CDD:214568	100/273 (37%)
		PTKc_Ack_like	137..398	CDD:270636	102/271 (38%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
AgaP_AGAP008317	XP_317149.4	SH3_Tec_like	159..212	CDD:212702	7/31 (23%)
		SH2_Tec_family	216..318	CDD:198188	16/105 (15%)
		PTKc_Tec_like	334..591	CDD:173637	103/280 (37%)
		Pkinase_Tyr	339..590	CDD:285015	100/273 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910