DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and AgaP_AGAP008813

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_314941.3	Gene:	AgaP_AGAP008813 / 1275672	VectorBaseID:	AGAP008813	Length:	1247	Species:	Anopheles gambiae

Alignment Length:	444	Identity:	105/444 - (23%)
Similarity:	159/444 - (35%)	Gaps:	163/444 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQ----QGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAA 183
            |:::..|.:.:.:.||||||.||:|.    |.:..|.:| ..||:|.:.::.........:.|..
Mosquito   775 NSEYEFPKERLKLGKQLGTGAFGVVMKATAQRIMVNEDE-TTVAVKMVKKQTDNEVMRALVSELK 838

  Fly   184 IM-HSIEHENIVRLYGVV---LATDSLMLVTELAHLRSL-------------------------- 218
            || |..:|.|:|.|.|.|   :|...||::.|.....::
Mosquito   839 IMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNVQNFLLKHRPHFIDQINQETGEIDSSI 903

  Fly   219 -------------------LECLK----------------------------DSG---------- 226
                               ::.||                            |||
Mosquito   904 DKNQLRWSKCGYQYNRYVRIQGLKYVNLSFSTNNVNHHPLQHPTAFYHNNHIDSGSTQYVDPKKH 968

  Fly   227 ------LRVSFL--------------------------------------------------TIP 235
                  :|.|.|                                                  |..
Mosquito   969 LNSKGYVRHSGLQNMGMVDSCNTEVTAMTSVEGEYLNSVNSNEPLWRSNYGMDYKGPARTVNTTD 1033

  Fly   236 TLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNL 300
            .:| :|.||..||.||..::::|.||||||||:...:.|||.||||:|::....:|.|..   ..
Mosquito  1034 LVC-WASQIACGMEYLASRKVLHGDLAARNILLCDDNVVKICDFGLARSMYKSDNYKKKG---EA 1094

  Fly   301 KLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPD 365
            .||..|.|.|||....|:..|||||:|:.|||:||.|..|:..:...|.|.......| |:::|.
Mosquito  1095 PLPFKWLALECIGDNVFSTYSDVWAYGIVLWELFSLGKVPYPGMEANQELYNKLRDGY-RMDKPQ 1158

  Fly   366 CCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLL 419
            ....:.|.:|:.||......||.|.::..:...|.|:.:          :||.|
Mosquito  1159 YSNQDIYDIMLNCWNVKPDSRPSFKDLKSRFNAMLPDDM----------RDHYL 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	98/409 (24%)
		PTKc_Ack_like	137..398	CDD:270636	98/407 (24%)
		SH3	400..454	CDD:214620	4/20 (20%)
		CRIB	486..525	CDD:238077
AgaP_AGAP008813	XP_314941.3	Ig	180..286	CDD:299845
		IG	<325..393	CDD:214652
		Ig	528..601	CDD:143165
		IG_like	621..702	CDD:214653
		Ig	632..702	CDD:299845
		PKc_like	777..1185	CDD:304357	99/413 (24%)
		Pkinase_Tyr	785..1189	CDD:285015	98/409 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910