DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and AgaP_AGAP007715

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_308161.4	Gene:	AgaP_AGAP007715 / 1269516	VectorBaseID:	AGAP007715	Length:	1403	Species:	Anopheles gambiae

Alignment Length:	1338	Identity:	626/1338 - (46%)
Similarity:	783/1338 - (58%)	Gaps:	251/1338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEYPQIDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFI-GLSRPEIRRLRKFYEKH 64
            ||....||||||.|:|||||||::||||||||....|||.|||||.: ||||||||||||:|||:
Mosquito     8 MEPKVPDLYEFLAEAELQQYYNSLKNELKITNVTHLKYATDEDLRQVSGLSRPEIRRLRKYYEKY 72

  Fly    65 FPHSYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIP 129
            :||.||:||:||||.|.   |.|..|.            |..||:.......||||:||||||||
Mosquito    73 YPHGYLNKIRRLLQTPR---KDENNPN------------SPTSSVEPIKACPSPSKIPNNKHIIP 122

  Fly   130 ADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIV 194
            .|:|.||||||||||||||||||:||:|||||||||||||||||||||||||||:||||||||||
Mosquito   123 PDAICVNKQLGTGEFGIVQQGVWTNGSERIQVAIKCLCRERMQSNPMEFLKEAAMMHSIEHENIV 187

  Fly   195 RLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHR 259
            |||||||.|:||||||||||||||||||||.||||||||:|||||||.||||||.|||.||.|||
Mosquito   188 RLYGVVLDTESLMLVTELAHLRSLLECLKDPGLRVSFLTVPTLCEFASQICNGMMYLENKRFIHR 252

  Fly   260 DLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVW 324
            ||||||||||||:||||||||||||||||||||:||||||||||||||||||||:||||:|||||
Mosquito   253 DLAARNILVFSKNKVKISDFGLSRALGVGKDYYQTNFNVNLKLPIAWCAPECINFLRFTHASDVW 317

  Fly   325 AFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRF 389
            ||||||||:|||||||||||||.|||||||.|:|||||:|:|||.|||.||:||||.||||||:|
Mosquito   318 AFGVCLWEIFSYGFQPWAALTGHQILEAIDEPHYQRLEKPECCPKEYYALMLKCWQHDAAKRPKF 382

  Fly   390 GEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSN 454
            .:|:..|||:||||||.:|..:|.|||:|:||||:||:|||:|...|:|||||::||||.|||:|
Mosquito   383 SDIFLMLPDIKPEQLKTIVAYSEHKKDYLMYRQGEIITVLDKNNNAPYWKGVLNSGKTGLFNPAN 447

  Fly   455 TVAFLEGLPSS-TRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQ 518
            |||:|:.|||| .||:|.|.:: |.||||:||:|||:||||.||||||||||.:|||:|||.|.|
Mosquito   448 TVAYLDSLPSSVNRDNFCRTAE-RSSKRKIRTDMISRPQNDLKHTGHVGIDGVSFGDVAFLSSPQ 511

  Fly   519 NYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSGGAMGTSMNPTFIPSA 583
            |.:::|:|||||||||||:||||||||||||||||:|||||||.|.....|      :.:||.:.
Mosquito   512 NVSNLPRQIVTPYKPSEDLEQTPLLLPPTPTSPDSIQTASGYFSETLQLAG------HQSFINAG 570

  Fly   584 EHTPKLIATNG----------QSSFDFASG---STNPFFPNRGDDELEFGLHNYGADGKSVHSET 635
            |:...:|...|          .|:|||.:.   .:|||.  ..||         ..|..:.::.|
Mosquito   571 ENHHHIIDHGGTASTVVDGLTTSAFDFRNSGFKDSNPFI--NADD---------NGDNAAAYNNT 624

  Fly   636 GWRPTSRSIVDDPHEYHEISDDEIAADKL-DFGPSLLDEINSMFGSISAATGSH-PKSPGFDHVN 698
            ....:||. ..:.|||||||||:||.:|: |.||||:||:..:|.|:|..:... |.||..::.|
Mosquito   625 AVATSSRD-GQNQHEYHEISDDDIATEKVFDQGPSLMDEMEHVFKSMSTISEQGVPLSPDAENTN 688

  Fly   699 NKNEITEMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKILNHAIEIANEISAR 763
            .:||:.|:|:|:.:|:...|........:.:.:|.|.:.||||||:||||:||..||:||||||:
Mosquito   689 MRNELAELSSKMSRKTTSINVRFSLLSFVGSKAKPKKASTVKPISMKDEKLLNQVIEMANEISAK 753

  Fly   764 SMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGN--ASPFPKKKNFT 826
            ||.|||:|......||||||||||||:.|...||..|.|..:|. |.|...|  .:.:.:|:||:
Mosquito   754 SMTDLVTDANHQTLSPKRKFSFRFPHIHNVVGGDDHGILSGAGQ-HHPHSSNTLTNSYREKRNFS 817

  Fly   827 EELQSIPDIQ---------RFRSL----------------------SEIKNSTDLRVPIFDK-ES 859
            :|:.::||:|         .:.||                      |....||..|..:.:. .:
Mosquito   818 QEVNNVPDLQSTITEEARIAYNSLVENPCTSGASGGFSNSVGQGGNSSFTCSTLPRAKLTNSLAT 882

  Fly   860 SDFLFQKSREILSRPLNLERECGDEQPPKSID------------DNIMDIENTLKAL-NLDFMHT 911
            :.|.| |..:..|.|        .|..|||.:            |||....|.|:.: |.:|...
Mosquito   883 ASFRF-KDIDCCSPP--------SEPAPKSPEEADLLLSEGSMCDNITAECNPLRMMRNKNFSIV 938

  Fly   912 YTELDKSDSNDTILNDQLPHMASLDDGISSATGS---------LKSAVYSYSNGV-QTMFDFNAA 966
                  ..|.:.|...|:|....||    :|:||         |.:..|:|:|.: .|:.:...|
Mosquito   939 ------PRSKNKISTHQVPWEEQLD----TASGSTNQAESPSYLTNPEYTYNNALTSTLTETRTA 993

  Fly   967 TS-----------------------HLDKH--------LQYMHNQAQLSAAAPVDPKP------- 993
            ..                       |:.|:        ||...|  :::...|:|.|.
Mosquito   994 AEGTDNPIPLPPRDRNKTIPVNQKRHVRKYPLIIPAAGLQRTLN--KVTQVTPIDEKSDVFSITD 1056

  Fly   994 -----------MDDKRSSTPD-------------------TGFASRDTNISLSRRSSQKSSYSPQ 1028
                       .||...:.||                   ...|..|...:.:.:.:|:..||.:
Mosquito  1057 TAEPTTAGNNIHDDHLRNDPDECSNLDVLHKSIESIKLGEIDEALTDLPSNATEQLAQQKGYSKE 1121

  Fly  1029 ESFHFPLKGEPLFSAPPVVMSGGYASLKDELGYERFGNGATKQMLASASPIKSGV---GLNASSG 1090
                |.....|..||.|:.|..|      |.......|..|...|.:..|..|.:   ...||..
Mosquito  1122 ----FLQNNFPSVSANPLPMVCG------EQHSSTLSNKITTTTLPATIPAASAILTRRRTASDA 1176

  Fly  1091 SVYMGSKGYRQRSTSFNESFHPISPVLSEPPQRERGVIQRQVRLEQQQPLPRRSASYKPRS-IRA 1154
            || :|:...|::            |....||                 |.|...:|..|.| .|.
Mosquito  1177 SV-LGASAQRRQ------------PPPPPPP-----------------PAPLMLSSIAPESESRD 1211

  Fly  1155 RTLRRL----SYNPMTLDSSSSSGEEPVKPSLARSECD 1188
            .|...|    ::|...:|::|...|     |:..::.|
Mosquito  1212 PTYENLDIFQTHNSFCIDTASLHCE-----SILENDAD 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	45/61 (74%)
		STYKc	133..396	CDD:214568	231/262 (88%)
		PTKc_Ack_like	137..398	CDD:270636	229/260 (88%)
		SH3	400..454	CDD:214620	35/53 (66%)
		CRIB	486..525	CDD:238077	26/38 (68%)
AgaP_AGAP007715	XP_308161.4	SAM_TNK-like	11..73	CDD:188938	45/61 (74%)
		STYKc	126..385	CDD:214568	230/258 (89%)
		PTKc_Ack_like	130..391	CDD:270636	229/260 (88%)
		SH3	393..447	CDD:214620	35/53 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0199
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H81410
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26355
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.890