Protein Alignment Ack-like and LMTK3

DIOPT Version :9

• Sequence 1: NP_001260935.1
• Gene: Ack-like / 36442
• FlyBaseID: FBgn0263998
• Length: 1495
• Species: Drosophila melanogaster
• Sequence 2: XP_011524713.1
• Gene: LMTK3 / 114783
• HGNCID: 19295
• Length: 1486
• Species: Homo sapiens
• Alignment Length: 1632
• Identity: 335/1632 - (20%)
• Similarity: 517/1632 - (31%)
• Gaps: 556/1632 - (34%)

  Fly   116 SSPSKVPNNKHI-------IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQS 173
            |.|...|...|.       :....:|..:::|:|.||.|..|...:.....||.:|.|   |..:
Human   135 SLPMPAPQPSHSDMTTPLGLSRQHLSYLQEIGSGWFGKVILGEIFSDYTPAQVVVKEL---RASA 196

  Fly   174 NPME---FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK----DSGLRVSF 231
            .|:|   |:.||....|::|.|:::..|:.:.|...:|:.|...|..|...|:    ..||....
Human   197 GPLEQRKFISEAQPYRSLQHPNVLQCLGLCVETLPFLLIMEFCQLGDLKRYLRAQRPPEGLSPEL 261

  Fly   232 --LTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKT 294
              ..:.||....|:|..|:.:|.....:|.|||.||.|:.|...|:|.|:||:.: ...:|||.|
Human   262 PPRDLRTLQRMGLEIARGLAHLHSHNYVHSDLALRNCLLTSDLTVRIGDYGLAHS-NYKEDYYLT 325

  Fly   295 NFNVNLKLPIAWCAPECINYLRFT-------NASDVWAFGVCLWEMFSYGFQPWAALTGLQILEA 352
              ...|.:|:.|.|||.:..|..|       ..|::|:.||.|||:|.:|.||:..|:..::|..
Human   326 --PERLWIPLRWAAPELLGELHGTFMVVDQSRESNIWSLGVTLWELFEFGAQPYRHLSDEEVLAF 388

  Fly   353 IDAPNYQRLEQPDC---CPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPK 414
            :....:.:|.:|..   ....:|.::..||: ..|:||...::..||..:..|:.........|.
Human   389 VVRQQHVKLARPRLKLPYADYWYDILQSCWR-PPAQRPSASDLQLQLTYLLSERPPRPPPPPPPP 452

  Fly   415 KD----------HLLYRQG------------------DIISVLD-------------------RN 432
            :|          |...|.|                  |:::|.:                   |.
Human   453 RDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLWEKARRGAGRG 517

  Fly   433 TGTPFWKGVLSTGKTGYFNPSNTVAFLEGL-------------PSSTRDSFSRVSDHRISKRKLR 484
            .|.|.|:.. |.....:.||||  .|.|.|             ||.:.:.:.|:.:|.
Human   518 GGAPAWQPA-SAPPAPHANPSN--PFYEALSTPSVLPVISARSPSVSSEYYIRLEEHG------- 572

  Fly   485 TEMISKPQ----NDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSE------DIEQ 539
                |.|:    ||:        |....|             ||.. ..|..|||      :...
Human   573 ----SPPEPLFPNDW--------DPLDPG-------------VPAP-QAPQAPSEVPQLVSETWA 611

  Fly   540 TPLLLPPTPTSPDSLQTASGYF------PEGANSG-----------GAMGTSMNPTFIP--SAEH 585
            :||...|.|....|  :|||.|      |||..:|           |..||:      |  ..|.
Human   612 SPLFPAPRPFPAQS--SASGSFLLSGWDPEGRGAGETLAGDPAEVLGERGTA------PWVEEEE 668

  Fly   586 TPKLIATNGQSSFDFASG------------------STNPFFPNRGDDELEFGLH------NYGA 626
            ..:..::.|:.|.....|                  |..|.  .|||....:|.|      :...
Human   669 EEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACSCLPL--ERGDAVAGWGGHPALGCPHPPE 731

  Fly   627 DGKSVHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHP-- 689
            |..|:.:|.|      |:.|.|           .|......|..||.:      :.||...:|
Human   732 DDSSLRAERG------SLADLP-----------MAPPASAPPEFLDPL------MGAAAPQYPGR 773

  Fly   690 -----------------------------KSPGFDHVNNKNEITEMSAKLGQKSGDTNGNKHGHG 725
                                         .|||       :.::....|.|....:|.......|
Human   774 GPPPAPPPPPPPPRAPADPAASPDPPSAVASPG-------SGLSSPGPKPGDSGYETETPFSPEG 831

  Fly   726 LLPTLSKKKSSGTVKP---------------------------------ISVKDEKILNHAIEIA 757
            ..|.....:..|..:|                                 :.|..|::|
Human   832 AFPGGGAAEEEGVPRPRAPPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLL------- 889

  Fly   758 NEISARSMI--DLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPT-HGNASPF 819
              :|.|..:  :|:.::.........:.:.|.|     |:.:|..||.     ..|| .||....
Human   890 --MSLREDVTRNLLGEKGATARETGPRKAGRGP-----GNREKVPGLN-----RDPTVLGNGKQA 942

  Fly   820 PKKKNFTEELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILSRPLNLER--ECG 882
            |.        .|:|    ...::.::|. |.|.|..::::::      ...|..|...|:  |.|
Human   943 PS--------LSLP----VNGVTVLENG-DQRAPGIEEKAAE------NGALGSPEREEKVLENG 988

  Fly   883 DEQPPKSIDDNIMDIENTLKALNLDFMHTYTELDKSDSNDTIL-NDQLPHMASLDDGISSATGSL 946
            :..||:..:          |||.      ..||...::.:.:| |..|....| :|.:|...|
Human   989 ELTPPRREE----------KALE------NGELRSPEAGEKVLVNGGLTPPKS-EDKVSENGG-- 1034

  Fly   947 KSAVYSYSNGVQTMFDFNAATSHLDKHLQYMHNQAQLSAAAP-VDPKPMDDKRSS---TPDTGFA 1007
                                       |::..|..:.....| ..|.|.:....|   .|..|..
Human  1035 ---------------------------LRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEP 1072

  Fly  1008 SRDTNISLSRRSSQKSSYSPQESFHFPLKGE----PLFSAPP-VVMSGGYASLKDELGYERFGNG 1067
            :.:|  ||.|..:..:..|.:..      ||    ||..||. ..:..|......|.|......|
Human  1073 APET--SLERAPAPSAVVSSRNG------GETAPGPLGPAPKNGTLEPGTERRAPETGGAPRAPG 1129

  Fly  1068 ATKQMLASA--SPIKSGVGLNASSGSVYMGSKGYRQRSTSFNESFHPISPVLSEPPQRERGVIQR 1130
            |.:..|.|.  :|:.:|.......||......|:..     |....|..|.|..||:.:
Human  1130 AGRLDLGSGGRAPVGTGTAPGGGPGSGVDAKAGWVD-----NTRPQPPPPPLPPPPEAQ------ 1183

  Fly  1131 QVRLEQQQPLPRRSASYKPRSIRARTLRRLSYNPMTLDS-----SSSSGE-EPVKPSLARSECDI 1189
                      |||   .:|...|||........|...||     ::.||: :|.||
Human  1184 ----------PRR---LEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKP--------- 1226

  Fly  1190 RARVAASSNSSLGRRRRAGMNRQVQSACHDEREVIISPRQMYGSNSSIKS--------------A 1240
                         .|:...|.|..         :.:.|.|  |::..||:              .
Human  1227 -------------ERKGPEMPRLF---------LDLGPPQ--GNSEQIKARLSRLSLALPPLTLT 1267

  Fly  1241 PHYNIGGQRRSFHRGGPGVMGGGYEQFQYDERIYDFGGRG-PGNNYNMAQASYLSSSQKPSYLLN 1304
            |....|.:|..:.....|..||            :.||.| ||                |:....
Human  1268 PFPGPGPRRPPWEGADAGAAGG------------EAGGAGAPG----------------PAEEDG 1304

  Fly  1305 GSELPGSGSGSSSAASSAVQATYRPGAGTSVQRPMSGGAALHEFDISR-LTG--KSPTSTNFVGS 1366
            ..|.........:||..|......||...:...|:...:|  :.|.:| |.|  |||...:....
Human  1305 EDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSA--DADAARPLRGLLKSPRGADEPED 1367

  Fly  1367 SPEELKQRQLSV-GSL-------QTPNNKV---AKPQRPTEFHWPEKIHASAVKQHEMHWRQVHQ 1420
            |..|.|::.:|. |.:       :||.|::   |.|:..|:   |....|.....|
Human  1368 SELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEGDTD---PSTPPAPPTPPH--------- 1420

  Fly  1421 QQSLPTASIITAAVGGAVSARRSSDSSSSSSTESGDEFQ----------FRREFVAPRI----PP 1471
                      .|..|....   |:||....|.|..::|.          |.|..|:|.:    ||
Human  1421 ----------PATPGDGFP---SNDSGFGGSFEWAEDFPLLPPPGPPLCFSRFSVSPALETPGPP 1472

  Fly  1472 SPAPXLR 1478
            :.|| .|
Human  1473 ARAPDAR 1479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	81/281 (29%)
		PTKc_Ack_like	137..398	CDD:270636	82/279 (29%)
		SH3	400..454	CDD:214620	15/100 (15%)
		CRIB	486..525	CDD:238077	7/42 (17%)
LMTK3	XP_011524713.1	STYKc	159..434	CDD:214568	81/281 (29%)
		PTKc_Aatyk3	161..436	CDD:271108	82/281 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910