DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Abl2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_033725.2	Gene:	Abl2 / 11352	MGIID:	87860	Length:	1182	Species:	Mus musculus

Alignment Length:	1040	Identity:	239/1040 - (22%)
Similarity:	375/1040 - (36%)	Gaps:	322/1040 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSR----PEIRRLRKFYEKHFP 66
            :.||:|:...:         |.|.||..        |.||.:|.::    .|:|  .|..:...|
Mouse   113 VALYDFVASGD---------NTLSITKG--------EKLRVLGYNQNGEWSEVR--SKNGQGWVP 158

  Fly    67 HSYLSKIKRL---------------------LQAPGTMVKREEAPGGGSQVAL--DG-------- 100
            .:|::.:..|                     |.....:|:..|:..|...::|  :|
Mouse   159 SNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRIN 223

  Fly   101 ---------SSASACSSLA--------AKNGASSPSKVP---------------NNKHIIPADSI 133
                     ::.|..|:||        ..:|..:....|               ::|..:....|
Mouse   224 TTTDSKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDI 288

  Fly   134 SVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYG 198
            ::..:||.|::|.|..|||...:  :.||:|.|..:.|:..  |||||||:|..|:|.|:|:|.|
Mouse   289 TMKHKLGGGQYGEVYVGVWKKYS--LTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQLLG 349

  Fly   199 VVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAA 263
            |........:|||.....:||:.|::.....  :|...|...|.||.:.|.|||:|..|||||||
Mouse   350 VCTLEPPFYIVTEYMPYGNLLDYLRECSREE--VTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412

  Fly   264 RNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGV 328
            ||.||.....||::|||||| |..|..|   ..:...|.||.|.|||.:.|..|:..||||||||
Mouse   413 RNCLVGENHVVKVADFGLSR-LMTGDTY---TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGV 473

  Fly   329 CLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIY 393
            .|||:.:||..|:..:...|:.:.:: ..| |:|||:.||.:.|.||..||:...|.||.|.|.:
Mouse   474 LLWEIATYGMSPYPGIDLSQVYDLLE-KGY-RMEQPEGCPPKVYELMRACWKWSPADRPSFAETH 536

  Fly   394 DQLPDM---------KPEQLKAVVNCTE-----------PKKDHLLYRQGDIISVLDRNTGTPFW 438
            .....|         ..|:|....:.:.           |.|...|.:||:....||
Mouse   537 QAFETMFHDSSISEEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLRKQGENKENLD-------- 593

  Fly   439 KGVL--------STGKTGYFNPSNTVAFLEGLPSSTRDS-------------FSRVSDHR----- 477
             |.|        |:...|:...:...:....||...||.             |:|  |.:
Mouse   594 -GGLDAAESLASSSAPAGFIRSTQASSGSPALPRKQRDKSPSSLLEDAKETCFTR--DRKGGFFS 655

  Fly   478 --ISKRKLRT---------EMISKPQNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPY 531
              :.||...|         ||.::|...::.||:       |..:|.|..:..::..|.|
Mouse   656 SFMKKRNAPTPPKRSSSFREMENQPHKKYELTGN-------FSPVASLQHADGFSVAPSQ----- 708

  Fly   532 KPSEDIEQTPLLLPPTPTSPDSLQTASGYF-------PEGANSGGAMGTSMNPTFIPSAEHTPKL 589
                   |.|.|:|        .:...|.|       .:.:..||..||:.......:...||:|
Mouse   709 -------QEPNLVP--------AKCYGGSFAQRNLCADDDSGGGGGSGTAGGGWSGITGFFTPRL 758

  Fly   590 I-ATNG-QSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHEYH 652
            | .|.| ::....||..|:..||.               ...:....:|.....|..:..|....
Mouse   759 IKKTLGLRAGKPTASDDTSKPFPR---------------SNSTSSMSSGLPEQDRMAMTLPRNCQ 808

  Fly   653 EISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQKSGDT 717
            .        .||..             ..:.:|.|.|:    ::|:..|::      |.:||.:
Mouse   809 R--------SKLQL-------------ERTVSTSSQPE----ENVDRANDM------LPKKSEE- 841

  Fly   718 NGNKHGHGLLPTLSKKKS-----SGTVKPISVKDEKIL---NHAIEIANEISARSMIDLVSDQTP 774
                   |..|...:.|:     ..|..|:...|..|.   :..:.:|.
Mouse   842 -------GAAPARERPKAKLLPRGATALPLRAPDPAITESDSPGVGVAG---------------- 883

  Fly   775 VIHSPKRKFSFRFPHLSNNGSGDKSGG--LGTSGSAHTPTHGN----ASP------FPKKKNFTE 827
            |..:||.|              :::||  ||.:|   .|..|.    :||      .|...|...
Mouse   884 VAAAPKGK--------------ERNGGTRLGVAG---VPEDGEQLGWSSPAKAVAVLPTTHNHKV 931

  Fly   828 ELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKSREILS-----RPLNLERECGDEQPP 887
            .:...|.::.        ...|:::...|.:.:.|......::.|     ||..::.:|....||
Mouse   932 PVLISPTLKH--------TPADVQLIGTDSQGNKFKLLSEHQVTSSGDKDRPRRVKPKCAPPPPP 988

Fly 888 887
Mouse 989 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	14/62 (23%)
		STYKc	133..396	CDD:214568	108/262 (41%)
		PTKc_Ack_like	137..398	CDD:270636	107/260 (41%)
		SH3	400..454	CDD:214620	13/72 (18%)
		CRIB	486..525	CDD:238077	8/38 (21%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		CAP	2..106
		SH3_Abl	111..164	CDD:212784	16/69 (23%)
		SH2_ABL	169..262	CDD:198189	11/92 (12%)
		PTKc_Abl	281..543	CDD:270645	108/273 (40%)
		STYKc	288..539	CDD:214568	108/262 (41%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..642		4/29 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..674		3/18 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	659..661		0/1 (0%)
		F-actin-binding	695..930		60/341 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..796		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858		13/87 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1059		6/25 (24%)
		F-actin-binding	1020..1182
		FABD	1063..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910