DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and Abl1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	NP_001106174.1	Gene:	Abl1 / 11350	MGIID:	87859	Length:	1142	Species:	Mus musculus

Alignment Length:	1185	Identity:	268/1185 - (22%)
Similarity:	421/1185 - (35%)	Gaps:	322/1185 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IDLYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSR------------------- 51
            :.||:|:...:         |.|.||..        |.||.:|.:.
Mouse    86 VALYDFVASGD---------NTLSITKG--------EKLRVLGYNHNGEWCEAQTKNGQGWVPSN 133

  Fly    52 --PEIRRLRKFYEKHFPHSYLSKIKRLLQA--PGTMVKR--EEAPGGGS--------------QV 96
              ..:..|.|....|.|.| .:..:.||.:  .|:.:.|  |.:||..|              ..
Mouse   134 YITPVNSLEKHSWYHGPVS-RNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINT 197

  Fly    97 ALDG----SSASACSSLA----------------------AKNGASSPSKVPN-NKHIIPADSIS 134
            |.||    ||.|..::||                      .:|..:.....|| :|..:....|:
Mouse   198 ASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDIT 262

  Fly   135 VNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGV 199
            :..:||.|::|.|.:|||...:  :.||:|.|..:.|:..  |||||||:|..|:|.|:|:|.||
Mouse   263 MKHKLGGGQYGEVYEGVWKKYS--LTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQLLGV 323

  Fly   200 VLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAAR 264
            ........::||.....:||:.|::...:.  ::...|...|.||.:.|.|||:|..||||||||
Mouse   324 CTREPPFYIITEFMTYGNLLDYLRECNRQE--VSAVVLLYMATQISSAMEYLEKKNFIHRDLAAR 386

  Fly   265 NILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVC 329
            |.||.....||::|||||| |..|..|   ..:...|.||.|.|||.:.|.:|:..||||||||.
Mouse   387 NCLVGENHLVKVADFGLSR-LMTGDTY---TAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVL 447

  Fly   330 LWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYD 394
            |||:.:||..|:..:...|:.|.:: .:| |:|:|:.||.:.|.||..|||.:.:.||.|.||:.
Mouse   448 LWEIATYGMSPYPGIDLSQVYELLE-KDY-RMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 510

  Fly   395 QLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYFNPSNTVAFL 459
            ....|                    :::..|...:::           ..||.|....:.::...
Mouse   511 AFETM--------------------FQESSISDEVEK-----------ELGKRGTRGGAGSMLQA 544

  Fly   460 EGLPSSTR-----------------------------DSFSRVS-----------------DHRI 478
            ..||:.||                             ||...||                 |.|:
Mouse   545 PELPTKTRTCRRAAEQKDAPDTPELLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERL 609

  Fly   479 SKRKLRTEMIS--------------KPQNDFKH-TGHVGIDGATFGDIAFLGSSQNYNHVPKQIV 528
            ..|..:|.:.|              |..:.|:. .|.....||:..|      |:...:.|
Mouse   610 LPRDRKTNLFSALIKKKKKMAPTPPKRSSSFREMDGQPDRRGASEDD------SRELCNGP---- 664

  Fly   529 TPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGANSG--------------GA--------M 571
             |...|:..|.|     .:|.:.:.....:|.|.|..|||              |:        .
Mouse   665 -PALTSDAAEPT-----KSPKASNGAGVPNGAFREPGNSGFRSPHMWKKSSTLTGSRLAAAEEES 723

  Fly   572 GTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGD--DELEFGLHNYGADGKSVHSE 634
            |.|.:..|:.|...:   ...:|....::.|.:.....|:.|.  |...||.|.         ||
Mouse   724 GMSSSKRFLRSCSAS---CMPHGARDTEWRSVTLPRDLPSAGKQFDSSTFGGHK---------SE 776

  Fly   635 TGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLL----DEINSMFGSISAATGSHPKSPGFD 695
            ....|..|:        .|...:::|.......|.|:    :.....|....::.||.|  |...
Mouse   777 KPALPRKRT--------SESRSEQVAKSTAMPPPRLVKKNEEAAEEGFKDTESSPGSSP--PSLT 831

  Fly   696 HVNNKNEIT-EMSAKLGQKSGDTNGNKHGHGLLPTLSKKKSSGTVKPISVKDEKIL----NHAIE 755
            ....:.::| ..|:.|..|...|.|:..|.|...|......|..|.......|::.    .|:.|
Mouse   832 PKLLRRQVTASPSSGLSHKEEATKGSASGMGTPATAEPAPPSNKVGLSKASSEEMRVRRHKHSSE 896

  Fly   756 IANEISAR-SMIDLVSDQTPVIHSPKRKFSFRFPHLSNNGSGDKSGG-------------LGTSG 806
            .......| :.:.......|.......|     |..|.:....::||             :.|..
Mouse   897 SPGRDKGRLAKLKPAPPPPPACTGKAGK-----PAQSPSQEAGEAGGPTKTKCTSLAMDAVNTDP 956

  Fly   807 S-AHTPTHGNASPFP---KKKNFTEELQSIPDIQRFRSLSEIKNSTDLRVP---IFDKESSDFLF 864
            : |..|..|...|.|   .|...|.:....|       .|.:...:....|   ..|::.|...|
Mouse   957 TKAGPPGEGLRKPVPPSVPKPQSTAKPPGTP-------TSPVSTPSTAPAPSPLAGDQQPSSAAF 1014

  Fly   865 QKSREILSRPLNLERECGDEQPPKSIDDNIMDIENTLKALNLDFMHTYTE---LDKSDSNDTILN 926
               ..::|..::|.:   ..|||:.|...                 |.|:   ||.:::....::
Mouse  1015 ---IPLISTRVSLRK---TRQPPERIASG-----------------TITKGVVLDSTEALCLAIS 1056

  Fly   927 DQLPHMASLDDGISSATGSLKSAVYSYSNGVQTM---FDFNAATSHLDKHLQYMHNQAQLSAAAP 988
            .....||| ...:..|..:|.:...||.:.:|.|   |.|..|.:.|:.:|:.:......:::.|
Mouse  1057 RNSEQMAS-HSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATASSGP 1120

  Fly   989 VDPKPMDDKRSSTPD 1003
            ...:......||..:
Mouse  1121 AATQDFSKLLSSVKE 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	13/79 (16%)
		STYKc	133..396	CDD:214568	107/262 (41%)
		PTKc_Ack_like	137..398	CDD:270636	106/260 (41%)
		SH3	400..454	CDD:214620	4/53 (8%)
		CRIB	486..525	CDD:238077	8/53 (15%)
Abl1	NP_001106174.1	SH3_Abl	84..137	CDD:212784	11/67 (16%)
		SH2_ABL	142..235	CDD:198189	20/93 (22%)
		PTKc_Abl	254..516	CDD:270645	108/293 (37%)
		Pkinase_Tyr	261..512	CDD:285015	107/262 (41%)
		FABD	1018..1142	CDD:197885	27/139 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910