DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ack-like and MERTK

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:NP_006334.2 Gene:MERTK / 10461 HGNCID:7027 Length:999 Species:Homo sapiens


Alignment Length:478 Identity:135/478 - (28%)
Similarity:204/478 - (42%) Gaps:100/478 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 IIPADSISVNKQLGTGEFGIVQQG-VWSNGNERIQVAIKCLCRERMQSNPM-EFLKEAAIMHSIE 189
            :|..:.:.:.|.||.||||.|.:| :.......::||:|.:..:......: |||.|||.|....
Human   581 VIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFS 645

  Fly   190 HENIVRLYGVVLATDSL-----MLVTELAHLRSLLECLKDSGLRVSFLTIP--TLCEFALQICNG 247
            |.|::||.||.:...|.     |::........|...|..|.|......||  ||.:|.:.|..|
Human   646 HPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALG 710

  Fly   248 MRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECI 312
            |.||..:..:||||||||.::.....|.::|||||:.:..| |||:.....  |:|:.|.|.|.:
Human   711 MEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSG-DYYRQGRIA--KMPVKWIAIESL 772

  Fly   313 NYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNY----QRLEQPDCCPSEYYT 373
            ....:|:.||||||||.:||:.:.|..|:   .|:|..|..|   |    .||:||:.|..|.|.
Human   773 ADRVYTSKSDVWAFGVTMWEIATRGMTPY---PGVQNHEMYD---YLLHGHRLKQPEDCLDELYE 831

  Fly   374 LMMKCWQDDAAKRPRFG-------EIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDR 431
            :|..||:.|...||.|.       ::.:.|||::.:.....|| |:..:......||..::.||.
Human   832 IMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVN-TQLLESSEGLAQGSTLAPLDL 895

  Fly   432 NTGTPFWKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFS----RVSDHRISKRKLRTEMISKPQ 492
            |                 .:|.:.:|     ..:.|.:.|    .|.|             ||| 
Human   896 N-----------------IDPDSIIA-----SCTPRAAISVVTAEVHD-------------SKP- 924

  Fly   493 NDFKHTGHVGIDGATFGDIAFLGSS--QNYNHVPKQIVTPYK----PSEDIEQTPL------LLP 545
                |.|...::|         ||.  ::....|...||..|    |.|.:.:..:      :||
Human   925 ----HEGRYILNG---------GSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLP 976

  Fly   546 PTPTSPDSLQTASGYFPEGANSG 568
            ...:.||.|     .|.:.::.|
Human   977 LGSSLPDEL-----LFADDSSEG 994

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938
STYKc 133..396 CDD:214568 96/282 (34%)
PTKc_Ack_like 137..398 CDD:270636 97/280 (35%)
SH3 400..454 CDD:214620 9/53 (17%)
CRIB 486..525 CDD:238077 8/40 (20%)
MERTKNP_006334.2 IG 111..193 CDD:214652
Ig 111..176 CDD:143165
Ig2_Tyro3_like 199..279 CDD:143226
IG_like 203..280 CDD:214653
FN3 284..378 CDD:238020
FN3 386..478 CDD:238020
PTKc_Mer 579..862 CDD:271106 97/289 (34%)
Pkinase_Tyr 587..854 CDD:285015 96/275 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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