DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and hck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_005174178.1	Gene:	hck / 101885596	ZFINID:	ZDB-GENE-090313-72	Length:	499	Species:	Danio rerio

Alignment Length:	301	Identity:	115/301 - (38%)
Similarity:	170/301 - (56%)	Gaps:	20/301 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 SASACSSLAAKNGASSPSKVPNNKHI--IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIK 164
            |...|.||.:...:..|.| |..|..  ||.:|:.::|:||.|:||.|...::   |:..:||:|
Zfish   202 SDGLCQSLTSPCLSPKPQK-PWEKDAWEIPRESLKLDKRLGAGQFGEVWMAMY---NKHTKVAVK 262

  Fly   165 CLCRERMQSNPME-FLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLK-DSGL 227
            .:   :..|..:| ||.||.:|.|::|:.:|||..||...:.:.::||.....|||:.:| |.|.
Zfish   263 TM---KPGSMSVEAFLMEANLMKSLQHDKLVRLNAVVTKEEPIYIITEFMEKGSLLDFIKSDEGN 324

  Fly   228 RVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYY 292
            ||.   :|.|.:|:.||..||.|:||:..|||||.|.||||......||:||||:|.: ...:|
Zfish   325 RVQ---LPKLIDFSAQIAEGMAYIEQRNYIHRDLRAANILVNKSLVCKIADFGLARII-EDNEY- 384

  Fly   293 KTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPN 357
              ......|.||.|.|||.|||..||..||||:||:.|.|:.|||..|:..:|..:::.|::. .
Zfish   385 --TAREGAKFPIKWTAPEAINYGSFTIKSDVWSFGILLTEIISYGRTPYPGMTNPEVIRALER-G 446

  Fly   358 YQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            | |:::.|.||.|.|.:|::||::....||.|..:...|.|
Zfish   447 Y-RMQRLDSCPQELYDIMLECWKNKPEDRPTFEYLQSVLED 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	102/264 (39%)
		PTKc_Ack_like	137..398	CDD:270636	103/262 (39%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
hck	XP_005174178.1	SH3	58..109	CDD:302595
		SH2	113..215	CDD:301589	4/12 (33%)
		PTKc_Hck	222..487	CDD:270658	108/280 (39%)
		Pkinase_Tyr	234..484	CDD:285015	102/264 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920