DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and TNK2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_011510619.1	Gene:	TNK2 / 10188	HGNCID:	19297	Length:	1219	Species:	Homo sapiens

Alignment Length:	771	Identity:	244/771 - (31%)
Similarity:	355/771 - (46%)	Gaps:	176/771 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRRL------RKFYEKHFP 66
            |.|.|:|.:||||:..::::|.:|..:.|:|..:|||..||:.||..|||      ||...|.
Human   174 LLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKR-- 236

  Fly    67 HSYLSKI---KRL------LQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVP 122
            .|::||:   |||      ..:..|..|...||||   .|.:|...|....:..|:
Human   237 KSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGG---PAGEGPLQSLTCLIGEKD--------- 289

  Fly   123 NNKHIIPADSISVNKQLGTGEFGIVQQGVW-SNGNERIQVAIKCLCRERMQSNPM---EFLKEAA 183
                      :.:.::||.|.||:|::|.| :...:.:.||:||| :..:.|.|.   :|::|..
Human   290 ----------LRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCL-KPDVLSQPEAMDDFIREVN 343

  Fly   184 IMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECL-KDSGLRVSFLTIPTLCEFALQICNG 247
            .|||::|.|::||||||| |..:.:|||||.|.|||:.| |..|   .|| :.||..:|:|:..|
Human   344 AMHSLDHRNLIRLYGVVL-TPPMKMVTELAPLGSLLDRLRKHQG---HFL-LGTLSRYAVQVAEG 403

  Fly   248 MRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECI 312
            |.|||.||.|||||||||:|:.::|.|||.||||.|||....|:|.  ...:.|:|.||||||.:
Human   404 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYV--MQEHRKVPFAWCAPESL 466

  Fly   313 NYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMK 377
            ....|::|||.|.|||.|||||:||.:||..|.|.|||..||... :||.:|:.||.:.|.:|::
Human   467 KTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEG-ERLPRPEDCPQDIYNVMVQ 530

  Fly   378 CWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV- 441
            ||......||.|..:.|.|.:.:|..::|:.:..||.|.|:  :..|:|:|::......:|:|.
Human   531 CWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHI--QMNDVITVIEGRAENYWWRGQN 593

  Fly   442 LSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKP-QNDFKHTGHVGIDG 505
            ..|...|.| |.|.|..:.||  |.:|                   ||:| ||.|.||||...|.
Human   594 TRTLCVGPF-PRNVVTSVAGL--SAQD-------------------ISQPLQNSFIHTGHGDSDP 636

  Fly   506 A-TFG-----DIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEG 564
            . .:|     |..:||:..:...:....::..:|.:.:.......||.|..|       .:|
Human   637 RHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKREPPPRPPQP-------AFF--- 691

  Fly   565 ANSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFAS-GSTNPFFP-----------------N 611
                     :..||:.|.:|....|       |.||.. |...|..|                 :
Human   692 ---------TQKPTYDPVSEDQDPL-------SSDFKRLGLRKPGLPRGLWLAKPSARVPGTKAS 740

  Fly   612 RGDDE----LEFG--------------LHNYGADGKSVHSETGWRPTSRS---------IVD--- 646
            ||...    ::||              |.....|..|:..||..:..:|:         :||
Human   741 RGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDA 805

  Fly   647 ----DPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVN 698
                .|..|     |::|.|:.||      ||.|:..::..|  ..|..|.....|
Human   806 RPLPPPPAY-----DDVAQDEDDF------EICSINSTLVGA--GVPAGPSQGQTN 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	25/62 (40%)
		STYKc	133..396	CDD:214568	123/267 (46%)
		PTKc_Ack_like	137..398	CDD:270636	124/265 (47%)
		SH3	400..454	CDD:214620	15/54 (28%)
		CRIB	486..525	CDD:238077	15/45 (33%)
TNK2	XP_011510619.1	SAM_TNK-like	170..231	CDD:188938	22/56 (39%)
		STYKc	290..549	CDD:214568	123/267 (46%)
		PTKc_Ack_like	294..551	CDD:270636	124/265 (47%)
		SH3_9	559..608	CDD:291278	15/51 (29%)
		GTPase_binding	611..678	CDD:286160	20/87 (23%)
		Inhibitor_Mig-6	953..1017	CDD:288414
		UBA_ACK1	1140..1183	CDD:270460
		UBA_TNK1	1170..1209	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920