DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and ros1

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_031758565.1	Gene:	ros1 / 101733913	XenbaseID:	XB-GENE-991394	Length:	2240	Species:	Xenopus tropicalis

Alignment Length:	357	Identity:	124/357 - (34%)
Similarity:	178/357 - (49%)	Gaps:	50/357 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 ASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSN--GNER--IQVAI 163
            |:.|.:::.........|:||    .|.:.:::...||:|.||.|.:|...:  |.|.  .:||:
Frog  1891 ANGCYAVSILPTQKEKEKLPN----FPREKLTLCVFLGSGAFGEVYEGAAIDILGPETGIKKVAV 1951

  Fly   164 KCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLR 228
            |.|.|:.......||||||.:|...:|.||::|.||.|..:...::.||.....||..|:  |.|
Frog  1952 KTLKRDATDHEKTEFLKEAHLMSQFDHPNILKLLGVCLFNEPQYIILELMDGGDLLTYLR--GAR 2014

  Fly   229 V-SFLTIPTLCEFAL-----QICNGMRYLEQKRLIHRDLAARNILVFSKDK------VKISDFGL 281
            | ||...|.|....|     .|..|..|||:...:||||||||.||..|:.      |||.||||
Frog  2015 VDSFTQNPLLSTLDLLDISENISRGCAYLEKMHFVHRDLAARNCLVSVKEYNNPSRIVKIGDFGL 2079

  Fly   282 SRALGVGKDYYKTNF---NVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAA 343
            :|      |.||.::   |....||:.|.|||.:....||..||||:||:.|||:|:.|.||:..
Frog  2080 AR------DIYKCDYYRKNGEGLLPVRWMAPESLIDGIFTCRSDVWSFGIVLWEVFTMGQQPYPG 2138

  Fly   344 LTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVV 408
            .:.|::|..:.:.  ||:..|..||.:.::|:.|||..|..|||.|..:..||..:|...|:
Frog  2139 FSNLEVLHHVQSG--QRMCSPTNCPDDVWSLIQKCWAQDPWKRPAFSFLQKQLEKLKSYSLR--- 2198

  Fly   409 NCTEPKKD-----HLLYRQGDIISVLDRNTGT 435
             ||: |.|     :..:..|:       |||:
Frog  2199 -CTQ-KMDLEGVVNPAFEDGE-------NTGS 2221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	106/281 (38%)
		PTKc_Ack_like	137..398	CDD:270636	108/279 (39%)
		SH3	400..454	CDD:214620	10/41 (24%)
		CRIB	486..525	CDD:238077
ros1	XP_031758565.1	FN3	67..>134	CDD:238020
		FN3	166..247	CDD:238020
		FN3	529..631	CDD:238020
		fn3	1037..1112	CDD:394996
		FN3	1537..1636	CDD:238020
		FN3	1637..1726	CDD:238020
		PKc_like	1922..2190	CDD:419665	107/277 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910