DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and tnk2l

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_031755475.1	Gene:	tnk2l / 101732042	XenbaseID:	XB-GENE-22064896	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	644	Identity:	205/644 - (31%)
Similarity:	305/644 - (47%)	Gaps:	130/644 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYEFLTESELQQYYNAVKNELKITNAAQFKYAADEDLRFIGLSRPEIRR----LRKFYEKHFPHS 68
            |...|.|.:|:|:|:.:::.|.||....|.:....||..||:.||..||    ||:......|.|
Frog    10 LLALLREVQLEQFYSKLRDGLNITRPGHFDFVKPFDLDQIGMGRPGQRRLFEALRRRKPPVRPKS 74

  Fly    69 YLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSI 133
            ::.|:     .|.   |..|:|        :|..:...|.|..:..:|.       |.:|....:
Frog    75 WMYKV-----FPS---KNPESP--------EGPQSPEVSPLRMEPDSSM-------KCLINERDL 116

  Fly   134 SVNKQLGTGEFGIVQQGVW--SNGNERIQVAIKCLCRERMQSNP---MEFLKEAAIMHSIEHENI 193
            |:.::||.|.||:|::|.|  |:|.. :.||:|.| |....|:|   .:||:|...|:.::|.::
Frog   117 SLFERLGDGCFGVVRRGEWRVSSGRS-VNVAVKYL-RSDACSDPEALQDFLQEVNSMYVLDHPHL 179

  Fly   194 VRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIH 258
            :||||||| :..|.:|||:|.|.|||:.|.:|.......::|.|.:::|||.:||:|||..:.||
Frog   180 IRLYGVVL-SKPLKMVTEIAPLGSLLDALHNSYGSCGSFSLPLLWKYSLQIASGMKYLESYKFIH 243

  Fly   259 RDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDV 323
            ||||.||:|:.|:|..||.||||.||||...|:|  ..:.:.|:|.|||.||.:....|:|.|||
Frog   244 RDLATRNVLLTSEDVAKIGDFGLMRALGGHSDHY--IMSTHRKIPFAWCPPESLKIGAFSNQSDV 306

  Fly   324 WAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPR 388
            |.|||.|||||:||.:||...:|.|||..||. :.:.||:||.||...|.:|.|||..:..:||.
Frog   307 WMFGVTLWEMFTYGQEPWMGFSGKQILLKIDR-DRETLERPDDCPQALYEVMKKCWIYEPDQRPT 370

  Fly   389 FGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGV-LSTGKTGYF-- 450
            |..:...|...:|::::...:..:|  ..|....||:::|::..:..|.|:|. ..|.|.|.|
Frog   371 FANLMGLLSAARPQEVRIQRDFNDP--SCLQLESGDVVTVIEAGSDMPLWRGQNKRTLKVGRFPA 433

  Fly   451 ---------------NPSNTVAFLEGLP-SSTRDSFSRVSD-------------HRISKRKLRTE 486
                           ..|.::..|.|:. .|..|..:|:.|             .||||   ..|
Frog   434 SIVVTRDLPQFQVSGRQSTSLMQLPGIEGESENDRRNRIKDKGRKADRSNLLGMQRISK---SLE 495

  Fly   487 MISKP-------QNDFKHTGHVGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQT---P 541
            .||:|       |...::..|         |:    .|...|..|::|       .||.|.   .
Frog   496 SISEPCVPANRQQPPMRNRAH---------DL----ESHPTNASPRRI-------SDIPQIRNFA 540

  Fly   542 LLLPPT---PTSPDS----------------------LQTASGYFPEGANSGGAMGTSM 575
            ::.||.   |..|.|                      .|:..|..|||...|.|:.||:
Frog   541 IMRPPVFPKPKRPASKERFIPSPNADFPAQSVGGGVPRQSPGGTGPEGDAGGKALRTSV 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	20/60 (33%)
		STYKc	133..396	CDD:214568	119/267 (45%)
		PTKc_Ack_like	137..398	CDD:270636	119/265 (45%)
		SH3	400..454	CDD:214620	13/71 (18%)
		CRIB	486..525	CDD:238077	9/45 (20%)
tnk2l	XP_031755475.1	SAM_TNK-like	6..67	CDD:188938	20/56 (36%)
		PKc_like	120..380	CDD:419665	119/265 (45%)
		SH3	385..436	CDD:418401	12/52 (23%)
		UBA_like_SF	606..649	CDD:419673
		UBA_like_SF	636..675	CDD:419673
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D426644at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010