DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and lck

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_012812855.2	Gene:	lck / 100497656	XenbaseID:	XB-GENE-6054021	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	357	Identity:	128/357 - (35%)
Similarity:	179/357 - (50%)	Gaps:	48/357 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 SYLSKIKRLLQAPGTMVKR---EEAPGGGSQVA--------------LDGSSASACSSLAAKNGA 115
            ||...::.|.|..|.:||.   .....||..::              ...||...|:.|......
Frog   156 SYSLSVRDLDQNQGEVVKHYKIRNLDNGGFYISPRKTFQTLQELVQHYRRSSDGLCTLLKEPCQT 220

  Fly   116 SSPSK--------VPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQ 172
            ..|.|        :|.||       :.:.|:||.|:||.|..|.: ||:.:  ||||.|....|
Frog   221 QRPQKPWWADEWEIPRNK-------LQLVKKLGAGQFGEVWMGYY-NGHTK--VAIKSLKPGTM- 274

  Fly   173 SNPMEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDS-GLRVSFLTIPT 236
             :|..||.||.:|..::|..:|||..|| ..:.:.:|||......|::.||.| ||:   |||..
Frog   275 -SPEAFLAEANLMKQLQHPRLVRLNAVV-TQEPIYIVTEYMEKGCLVDYLKTSEGLK---LTIYK 334

  Fly   237 LCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLK 301
            |.:.:.|:..||.:||.|..|||||.|.||||......||:||||:|.: |..:|   ......|
Frog   335 LIDMSAQVAEGMAFLEHKNYIHRDLRAANILVSESLCCKIADFGLARVI-VDNEY---TAKEGAK 395

  Fly   302 LPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDC 366
            .||.|.|||.|||..||..||||:|||.|.|:.:||..|:..:|..:::|.::. .| |:.|||.
Frog   396 FPIKWTAPEAINYGTFTIKSDVWSFGVLLTEIVTYGRIPYPGMTNPEVIENLER-GY-RMPQPDN 458

  Fly   367 CPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPD 398
            ||.|.|.||::||:::..:||.|..:...|.|
Frog   459 CPMELYELMLRCWKEEPEERPTFEFLRSLLED 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	108/263 (41%)
		PTKc_Ack_like	137..398	CDD:270636	109/261 (42%)
		SH3	400..454	CDD:214620
		CRIB	486..525	CDD:238077
lck	XP_012812855.2	SH3_Lck	59..112	CDD:212938
		SH2_Src_family	117..217	CDD:199827	13/60 (22%)
		PTKc_Lck_Blk	231..494	CDD:270652	113/282 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920