DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ack-like and tie1

DIOPT Version :9

Sequence 1:NP_001260935.1 Gene:Ack-like / 36442 FlyBaseID:FBgn0263998 Length:1495 Species:Drosophila melanogaster
Sequence 2:XP_002931650.3 Gene:tie1 / 100496664 XenbaseID:XB-GENE-922217 Length:1127 Species:Xenopus tropicalis


Alignment Length:332 Identity:111/332 - (33%)
Similarity:162/332 - (48%) Gaps:27/332 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    91 GGGSQVALDGSSASACSSLAAKNGASSPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNG 155
            |.|.:..|..||.:...|...:     |...|.:..::..:.|.....:|.|.||.|.:.:....
 Frog   792 GSGEETILQFSSGTLTLSRRPR-----PQTEPFSYPVLEWEDIKFEDVIGEGNFGQVIKAMIKKD 851

  Fly   156 NERIQVAIKCLCRERMQSNPMEFLKEAAIMHSI-EHENIVRLYGVVLATDSLMLVTELAHLRSLL 219
            .:::..|||.|.....:::..:|..|..::..: .|.||:.|.|.......|.:..|.|...:||
 Frog   852 GQKMNAAIKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLL 916

  Fly   220 ECLKDSGL------------RVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLAARNILVFSKD 272
            :.|:.|.:            ..|.||...|.:||..:..||:||.:|:.|||||||||:||....
 Frog   917 DFLRKSRVLETDPVFAKEHGTASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENL 981

  Fly   273 KVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFGVCLWEMFSYG 337
            ..||:||||||...|   |.|....   :||:.|.|.|.:||..:|..||||:|||.|||:.|.|
 Frog   982 VTKIADFGLSRGEEV---YVKKTMG---RLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLG 1040

  Fly   338 FQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPE 402
            ..|:..:|..::.|  :.|...|:|:|..|..|.|.||.:||:|...:||.|.:|..||..|. :
 Frog  1041 GTPYCGMTCAELYE--NLPQGYRMEKPRNCDDEVYELMRQCWRDRPYERPPFSQISIQLTRML-D 1102

  Fly   403 QLKAVVN 409
            ..||.||
 Frog  1103 ARKAYVN 1109

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ack-likeNP_001260935.1 SAM_TNK-like 4..65 CDD:188938
STYKc 133..396 CDD:214568 96/275 (35%)
PTKc_Ack_like 137..398 CDD:270636 97/273 (36%)
SH3 400..454 CDD:214620 4/10 (40%)
CRIB 486..525 CDD:238077
tie1XP_002931650.3 IG_like 124..203 CDD:214653
EGF_CA <222..247 CDD:238011
EGF_CA 306..336 CDD:238011
Ig 341..432 CDD:416386
Ig strand A 341..345 CDD:409353
Ig strand A' 351..355 CDD:409353
Ig strand B 358..367 CDD:409353
Ig strand C 375..380 CDD:409353
Ig strand C' 384..386 CDD:409353
Ig strand D 390..394 CDD:409353
Ig strand E 397..405 CDD:409353
Ig strand F 413..421 CDD:409353
Ig strand G 424..432 CDD:409353
fn3 448..511 CDD:394996
FN3 633..724 CDD:238020
PTKc_Tie1 826..1122 CDD:270671 103/293 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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