DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and LOC100494929

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_004917824.1	Gene:	LOC100494929 / 100494929	-ID:	-	Length:	1019	Species:	Xenopus tropicalis

Alignment Length:	393	Identity:	129/393 - (32%)
Similarity:	189/393 - (48%)	Gaps:	65/393 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNER-IQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHE 191
            |.|.:|.:.:.:|.||||.|..|.....::| |.||||.|.....:....:||.||:||...:|.
Frog   659 IDASAIRIERVIGAGEFGEVCSGRLRLPSKREICVAIKSLKAGYSEKQRRDFLGEASIMGQFDHP 723

  Fly   192 NIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRL 256
            ||:||.|||.....:|::||.....||...||...   ...|:..|......|.:||:||.....
Frog   724 NIIRLEGVVTKCKPVMIITEFMENGSLDTFLKKHD---GQFTVIQLVGMLRGIASGMKYLSDMNY 785

  Fly   257 IHRDLAARNILVFSKDKVKISDFGLSRALGVGKD-YYKTNFNVNLKLPIAWCAPECINYLRFTNA 320
            :|||||||||||.|....|:|||||||.|....: .|.|...   |:||.|.|||.|.|.:||:|
Frog   786 VHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAAYTTRGG---KIPIRWTAPEAIAYRKFTSA 847

  Fly   321 SDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAK 385
            ||||::|:.:||:.|||.:|:..::...:::||| ..| ||..|..||...:.||:.|||...:.
Frog   848 SDVWSYGIVMWEVISYGERPYWEMSNQDVIKAID-EGY-RLPPPMDCPVVLHQLMLDCWQKCRSD 910

  Fly   386 RPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGTPFWKGVLSTGKTGYF 450
            ||:||:                                 |::|||:...||.....|:...| :.
Frog   911 RPKFGQ---------------------------------IVNVLDKYIRTPSSLNELANSST-WQ 941

  Fly   451 NPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVGIDGATFGDIAFLG 515
            :||    ..:.:|.:|.:.:            |....:|:..::|...|:|     |...:.:|.
Frog   942 DPS----MHDSMPVTTVEQW------------LEAIKMSQYIDNFTMAGYV-----TLESVLYLS 985

  Fly   516 SSQ 518
            |::
Frog   986 SNE 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	107/264 (41%)
		PTKc_Ack_like	137..398	CDD:270636	106/262 (40%)
		SH3	400..454	CDD:214620	9/53 (17%)
		CRIB	486..525	CDD:238077	7/33 (21%)
LOC100494929	XP_004917824.1	EphR_LBD_A	46..217	CDD:198441
		FN3	342..448	CDD:238020
		FN3	449..540	CDD:238020
		EphA2_TM	560..659	CDD:373140	129/393 (33%)
		PTKc_EphR_A	659..925	CDD:270651	113/306 (37%)
		SAM_EPH-R	950..1010	CDD:188887	10/56 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910