DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and fgr

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_002934688.1	Gene:	fgr / 100493811	XenbaseID:	XB-GENE-6073541	Length:	519	Species:	Xenopus tropicalis

Alignment Length:	299	Identity:	111/299 - (37%)
Similarity:	160/299 - (53%)	Gaps:	27/299 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 IPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHEN 192
            |..||||::|:||.|.||.|.:|.|   |....||:|.|....|  :|..||:||.||..:.|:.
Frog   248 ITRDSISLDKKLGQGCFGDVWKGTW---NGTTNVAVKTLKPSTM--SPEAFLEEAQIMKKLRHDK 307

  Fly   193 IVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLI 257
            :|:||.|| :.:.:.:|||.....|||:.||:.  ....|.:|.|.:.:.||.:||.|:|:...|
Frog   308 LVQLYAVV-SEEPIYIVTEFMTKGSLLDYLKEG--EGHLLKLPQLVDMSGQIASGMAYIERMNYI 369

  Fly   258 HRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASD 322
            ||||.|.||||......||:||||:|.: ...:|   ......|.||.|.|||...|.:||..||
Frog   370 HRDLRAANILVGDNLICKIADFGLARLI-EDNEY---TARQGAKFPIKWTAPEAALYGKFTIKSD 430

  Fly   323 VWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRP 387
            ||:||:.:.|:.:.|..|:..::..::||.::. .| |:..|..||...:.||::||:.|..:||
Frog   431 VWSFGIMVCELVTKGRIPYPGMSNREVLEQVER-GY-RMPAPPACPPSLHELMLQCWRGDPEERP 493

  Fly   388 RFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDII 426
            .|..:...|.|        ....|||:     |:.||.|
Frog   494 TFEYLQSFLED--------YFTATEPQ-----YQPGDNI 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	99/262 (38%)
		PTKc_Ack_like	137..398	CDD:270636	98/260 (38%)
		SH3	400..454	CDD:214620	7/27 (26%)
		CRIB	486..525	CDD:238077
fgr	XP_002934688.1	SH3	72..125	CDD:388381
		SH2_Src_Fgr	130..230	CDD:198230
		PTKc_Src_Fyn_like	257..504	CDD:271105	98/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010