DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and erbb2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_002940420.3	Gene:	erbb2 / 100492078	XenbaseID:	XB-GENE-5938588	Length:	1323	Species:	Xenopus tropicalis

Alignment Length:	693	Identity:	173/693 - (24%)
Similarity:	269/693 - (38%)	Gaps:	207/693 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IRRLRKFYEKHFPHSYLSKIKRLLQ----APGTMVKREEAPGGGSQVALDGSSASACSSLAAKNG 114
            |||.::..:||       .::||||    .|.|       |.|.
Frog   674 IRRRKQLKKKH-------TMRRLLQDELVEPLT-------PSGA--------------------- 703

  Fly   115 ASSPSKVPNNKHIIPADSISVNKQ--LGTGEFGIVQQGVW--SNGNERIQVAIKCLCRERMQSNP 175
                  :||...:.......:.|.  ||:|.||.|.:|:|  ...|.:|.||||.|.........
Frog   704 ------IPNQAQMRILKETELKKMMILGSGAFGTVYKGIWIPDGENIKIPVAIKVLRENTSPKAN 762

  Fly   176 MEFLKEAAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEF 240
            .|.|.||.:|..:....:.||.|:.| |.::.|||:|.....||:.::::..|::...:...|
Frog   763 KEILDEAYVMAGVGSPYVCRLLGICL-TSTVQLVTQLMPYGCLLDYVRENKDRIASRDLLNWC-- 824

  Fly   241 ALQICNGMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIA 305
             :||..||.|||..||:||||||||:||.|...|||:||||:|.|.|.:..|..:..   |:||.
Frog   825 -VQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDETEYHADGG---KVPIK 885

  Fly   306 WCAPECINYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSE 370
            |.|.|.|.:.|||:.||||::||.:||:.::|.:|:..:...:|.:.::  ..:||.||..|..:
Frog   886 WMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLE--KGERLPQPPVCTID 948

  Fly   371 YYTLMMKCWQDDAAKRPRFGEIYDQLPDMKPEQLKAVVNCTEPKKDHLLYRQGDIISVLDRNTGT 435
            .|.:|:|||..|:..||:|.::..:|..|..:..:.||...|           :.::.....| |
Frog   949 VYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENE-----------EFLAQASPMT-T 1001

  Fly   436 PFWKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGH 500
            .|:..:|.                                                        .
Frog  1002 QFYSALLQ--------------------------------------------------------E 1010

  Fly   501 VGIDGATFGDIAFLGSSQNYNHVPKQIVTPYKPSEDIEQTPLLLPPTPTSPDSLQTASGYFPEGA 565
            ||:|.        |..::.| .||::   .:.||||:.........:..|...:|.......|.|
Frog  1011 VGMDD--------LVDAEEY-LVPQR---GFFPSEDVTSEHRSRISSTRSATEMQAEQALLQETA 1063

  Fly   566 NSGGAMGTSMNPTFIPSAEHTPKLIATNGQSSFDFASGSTNPFFPNRGDDELEFGLHNYGADGKS 630
            .||.|:..:|:              ..:|.|..|..|.....|.|.:.:
Frog  1064 PSGAALARTMS--------------ERSGGSGSDALSEGEYVFDPPQNE---------------- 1098

  Fly   631 VHSETGWRPTSRSIVDDPHEYHEISDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFD 695
               |:|          .||.|   :||.:.:.:        ||.:|.|......:.|.|.....:
Frog  1099 ---ESG----------SPHRY---TDDPLHSGE--------DETDSCFFEGDCISPSIPLHLPAE 1139

  Fly   696 HVNNKNEITEMSAKLGQKSGDTNGN--KHGHGLLPTLSKKKSS 736
            :||             ||.|:.|.:  |.....:.||.::||:
Frog  1140 YVN-------------QKDGERNHSPVKSQRTSVSTLERQKST 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	4/10 (40%)
		STYKc	133..396	CDD:214568	100/266 (38%)
		PTKc_Ack_like	137..398	CDD:270636	101/264 (38%)
		SH3	400..454	CDD:214620	7/53 (13%)
		CRIB	486..525	CDD:238077	6/38 (16%)
erbb2	XP_002940420.3	Recep_L_domain	56..168	CDD:395817
		Furin-like	184..340	CDD:395614
		Recep_L_domain	366..479	CDD:395817
		GF_recep_IV	511..642	CDD:405525
		PTKc_HER2	710..988	CDD:270684	104/286 (36%)
		RILP-like	<1157..1233	CDD:419964	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910