DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ack-like and ptk6

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_002942429.3	Gene:	ptk6 / 100490792	XenbaseID:	XB-GENE-22069031	Length:	563	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	128/429 - (29%)
Similarity:	206/429 - (48%)	Gaps:	61/429 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 YEFLTES---ELQQYYNAVKNELKI---------TNAAQFKYAADEDLRFIGLSRPEIRRLRKFY 61
            |.||.|.   |.|:::...|:..:.         ||.:....|:|:......||.......|.|.
Frog   156 YNFLAEEGTVEEQEWFFGEKSRTEAVNLLMDEGNTNGSFLIRASDKHGILYVLSVRHQDSTRHFK 220

  Fly    62 EKHFPH--------SYLSKIKRLLQAPGTMVKREEAPGGGSQVALDGSSASACSSLAAKNG--AS 116
            ....|.        ::...:|:|::   |..|:...||            ...:....||.  .|
Frog   221 IMRNPEGQFHLNNMTFFPDLKQLVE---TYCKKPICPG------------LTLTKPCVKNEPVVS 270

  Fly   117 SPSKVPNNKHIIPADSISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKE 181
            ..|.||.::...|.:..::.|:||.|.||.|.:|:|..   :::||:|.:.|:....:  .|:||
Frog   271 DLSPVPLDEWERPREEFTLVKRLGMGNFGQVHEGLWKG---KLKVAVKTIKRDATSQD--LFVKE 330

  Fly   182 AAIMHSIEHENIVRLYGVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICN 246
            .|.:.::.|:|::.||.|....|...:||||.....||..|:|  |....|.:....:.|.|:..
Frog   331 TAFLKTLHHKNLLSLYAVCSVGDPYYIVTELVPRGDLLNYLRD--LEKDELDVEGQLDIATQVAE 393

  Fly   247 GMRYLEQKRLIHRDLAARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPEC 311
            ||||||.:..|||||||||:|:...:..||:|||::|.  :...||   .:.:.::|..|.|||.
Frog   394 GMRYLESQNCIHRDLAARNVLMGRNNICKIADFGMARV--ILDSYY---VSASKEIPFKWTAPEA 453

  Fly   312 INYLRFTNASDVWAFGVCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMM 376
            :.|.|:|..||||:||:.|:|:.|.|.||:.||:..::||.::  ..||::.|..|.:..|.:|:
Frog   454 VEYGRYTVKSDVWSFGILLYEIMSLGMQPYPALSNYEVLEFLN--RGQRMKAPPSCSTRVYNIML 516

  Fly   377 KCWQDDAAKRPRFGEIYDQLPDM----------KPEQLK 405
            .||..:..:||.|.::...|.::          ||.|.|
Frog   517 TCWAWNPNERPSFDDLRTMLENLSNYEGSEVAPKPLQPK 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938	15/67 (22%)
		STYKc	133..396	CDD:214568	94/262 (36%)
		PTKc_Ack_like	137..398	CDD:270636	95/260 (37%)
		SH3	400..454	CDD:214620	4/6 (67%)
		CRIB	486..525	CDD:238077
ptk6	XP_002942429.3	SH3	104..161	CDD:418401	3/4 (75%)
		SH2	168..252	CDD:214585	15/86 (17%)
		STYKc	288..536	CDD:214568	94/261 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D539311at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920