DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ack-like and abl2

DIOPT Version :9

Sequence 1:	NP_001260935.1	Gene:	Ack-like / 36442	FlyBaseID:	FBgn0263998	Length:	1495	Species:	Drosophila melanogaster
Sequence 2:	XP_002937405.1	Gene:	abl2 / 100487790	XenbaseID:	XB-GENE-6459814	Length:	1100	Species:	Xenopus tropicalis

Alignment Length:	966	Identity:	242/966 - (25%)
Similarity:	355/966 - (36%)	Gaps:	263/966 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 ISVNKQLGTGEFGIVQQGVWSNGNERIQVAIKCLCRERMQSNPMEFLKEAAIMHSIEHENIVRLY 197
            |::..:||.|::|.|..|||...|  :.||:|.|..:.|:..  |||||||:|..|:|.|:|:|.
Frog   277 ITMKHKLGGGQYGEVYVGVWKKYN--LTVAVKTLKEDTMEVE--EFLKEAAVMKEIKHPNLVQLL 337

  Fly   198 GVVLATDSLMLVTELAHLRSLLECLKDSGLRVSFLTIPTLCEFALQICNGMRYLEQKRLIHRDLA 262
            ||........:|||..|..:||:.|::.....  :|...|...|.||.:.|.|||:|..||||||
Frog   338 GVCTLEPPFYIVTEYMHYGNLLDYLRECNREE--VTAVVLLYMATQISSAMEYLERKNFIHRDLA 400

  Fly   263 ARNILVFSKDKVKISDFGLSRALGVGKDYYKTNFNVNLKLPIAWCAPECINYLRFTNASDVWAFG 327
            |||.||.....||::|||||| |..|..|   ..:...|.||.|.|||.:.|..|:..|||||||
Frog   401 ARNCLVGENHVVKVADFGLSR-LMTGDTY---TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 461

  Fly   328 VCLWEMFSYGFQPWAALTGLQILEAIDAPNYQRLEQPDCCPSEYYTLMMKCWQDDAAKRPRFGEI 392
            |.|||:.:||..|:..:...|:.:.:: ..| |:|||:.||.:.|.||..|||.:.:.||.|.|.
Frog   462 VLLWEIATYGMSPYPGIDLSQVYDLLE-KGY-RMEQPEGCPPKVYELMRACWQWNPSDRPSFSET 524

  Fly   393 YDQLPDM---------KPEQL--KAVVNCTE---------PKKDHLLYRQGDIISVLDRNTGTPF 437
            :.....|         ..|:|  .||.:.:.         |.|...|.::.:....::   ||
Frog   525 HQAFETMFHDSNINEEVAEELGRTAVTSSSVSYQCRLPMLPSKSRTLKKKAENKENIE---GT-- 584

  Fly   438 WKGVLSTGKTGYFNPSNTVAFLEGLPSSTRDSFSRVSDHRISKRKLRTEMISKPQNDFKHTGHVG 502
              |..|...|.    |:|...|.|.|.:        |......||.|.:..|....|.|.|
Frog   585 --GDSSDNSTS----SSTPGLLHGSPVA--------SGSPALPRKQRDKSPSSLLGDTKET---- 631

  Fly   503 IDGATF-----GDIAFLGSSQNYNHVPKQIVTPYKPS---EDIEQTPLLLP-------------- 545
                ||     |  .|..|.......|:    |.|.|   .::|..|...|
Frog   632 ----TFTRDRKG--GFFSSFMKKKSAPQ----PPKRSSSFREMENQPHKRPELTGELPSFQQLDS 686

  Fly   546 -PTPTSPDSLQTASG-----YFPE---GANSGGAMGTSMNPTFIPSAEHTPKLI----------- 590
             .:|.||.|.:...|     :.||   |...||..|.        |...||:||
Frog   687 LDSPASPGSHKCYGGGSQRSFPPEDVIGGIGGGWTGI--------SGFFTPRLIKKTFGLRTGKS 743

  Fly   591 ATNGQSSFDF----ASGSTNPFFPNRGDDELEFGLHNYGADGKSVHSETGWRPTSRSIVDDPHE- 650
            .::|:....|    ::.|.:|..|.:  |.|...|      .::.|........:.||...|.|
Frog   744 GSSGEEPKPFPRSNSTSSMSPAVPEQ--DRLSMTL------PRNCHRTKVQLDRTTSISSQPEES 800

  Fly   651 YHEI--SDDEIAADKLDFGPSLLDEINSMFGSISAATGSHPKSPGFDHVNNKNEITEMSAKLGQK 713
            .|::  |..||...:....|.:|........:....||:..||....|..........:|
Frog   801 QHDLQRSGLEIQPVRDRVKPKMLPRTGVSERNGGLRTGADEKSSPNKHTGGATSAFSTAA----- 860

  Fly   714 SGDTNGNKHGHGLLPTL---SKKKSSGTVKPISVKDEKILNHAIEIANEISARSMIDLVSDQTPV 775
                    |.| .:|.|   |.:.:|..|:.:.:..   |.|..::..|
Frog   861 --------HNH-KVPVLISPSPRNASTEVQLVGMDS---LGHTFKLLQE---------------- 897

  Fly   776 IHSPKRKFSFRFPHLSNNGSGDKSGGLGTSGSAHTPTHGNASPF--------------PKKKNFT 826
             |.|.                       |......|:|....|.              |:.::..
Frog   898 -HVPP-----------------------TGSERDRPSHRRLKPKCAPPPPPNLRLLQPPQAEDTA 938

  Fly   827 EELQSIPDIQRFRSLSEIKNSTDLRVPIFDKESSDFLFQKS----REILSRPLNLERECGDEQPP 887
            ....::|.::|     ..|.|..:..|......:..|...:    |.:|.:|         :||.
Frog   939 TAAPTLPCLER-----TTKPSRPMLPPPPSVNQTGKLSNGAAGVGRSVLRKP---------KQPT 989

  Fly   888 KSIDDNIMDIENTLKALNLDFMHTYTELDKSDSNDTILNDQL----PHMASLDDG---ISSATGS 945
            :.:....:..|..|:...|                  |:|.|    |:...:|.|   :...||.
Frog   990 ERVPAEKISKEALLQCAGL------------------LSDALALPQPNSQLVDTGHQLLDYCTGY 1036

  Fly   946 LKSAVYSYSNGVQTMFDFNAATSHLDKHLQYMHNQAQLSAA-------APVDPKPM 994
            :.|.     :..:..|.|..|.|.|:..||    :.|:|:|       ||....|:
Frog  1037 VDSI-----SQTRNKFAFREAVSRLEVSLQ----ELQVSSAGSGGASTAPPGANPV 1083

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ack-like	NP_001260935.1	SAM_TNK-like	4..65	CDD:188938
		STYKc	133..396	CDD:214568	110/262 (42%)
		PTKc_Ack_like	137..398	CDD:270636	109/260 (42%)
		SH3	400..454	CDD:214620	12/64 (19%)
		CRIB	486..525	CDD:238077	9/43 (21%)
abl2	XP_002937405.1	SH3_Abl	100..153	CDD:212784
		SH2_ABL	158..251	CDD:198189
		PTKc_Abl	270..532	CDD:270645	110/266 (41%)
		F_actin_bind	984..1100	CDD:385063	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910